Literature DB >> 28722495

Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features.

Elizabeth E Hopp1, Stephanie M Cossette2, Suresh N Kumar2,3, Daniel Eastwood4, Ramani Ramchandran1,2, Erin Bishop1.   

Abstract

Sucrose non-fermenting related kinase (SNRK) is a serine/threonine kinase known to regulate cellular metabolism and adipocyte inflammation. Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. The number of SNRK positive (+) nuclei is increased in malignant tissue compared to benign tissue (21.03% versus 14.90%, p < .0431). The most strongly stained malignant SNRK+ nuclei were stage 1 compared to stage 2-4 disease. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.

Entities:  

Keywords:  Cancer biomarkers; Invasion & metastasis; Ovarian cancer

Mesh：

Substances：

Year:  2017        PMID： 28722495      PMCID： PMC6167932          DOI： 10.1080/07357907.2017.1337781

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  15 in total

1.  SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons.

Authors:  K Yoshida; M Yamada; C Nishio; A Konishi; H Hatanaka
Journal:  Brain Res       Date:  2000-08-11       Impact factor: 3.252

2.  Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study.

Authors:  Kian Behbakht; Michael W Sill; Kathleen M Darcy; Stephen C Rubin; Robert S Mannel; Steven Waggoner; Russell J Schilder; Kathy Q Cai; Andrew K Godwin; R Katherine Alpaugh
Journal:  Gynecol Oncol       Date:  2011-07-12       Impact factor: 5.482

3.  Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin.

Authors:  Amy K Rines; Michael A Burke; Richard P Fernandez; Olga V Volpert; Hossein Ardehali
Journal:  FASEB J       Date:  2012-08-08       Impact factor: 5.191

4.  Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.

Authors:  Kristin M Nieman; Hilary A Kenny; Carla V Penicka; Andras Ladanyi; Rebecca Buell-Gutbrod; Marion R Zillhardt; Iris L Romero; Mark S Carey; Gordon B Mills; Gökhan S Hotamisligil; S Diane Yamada; Marcus E Peter; Katja Gwin; Ernst Lengyel
Journal:  Nat Med       Date:  2011-10-30       Impact factor: 53.440

Review 5.  AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Authors:  D Grahame Hardie
Journal:  Nat Rev Mol Cell Biol       Date:  2007-10       Impact factor: 94.444

Review 6.  Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

Authors:  S Fogarty; D G Hardie
Journal:  Biochim Biophys Acta       Date:  2009-09-22

7.  A yeast gene that is essential for release from glucose repression encodes a protein kinase.

Authors:  J L Celenza; M Carlson
Journal:  Science       Date:  1986-09-12       Impact factor: 47.728

8.  AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Authors:  Dana M Gwinn; David B Shackelford; Daniel F Egan; Maria M Mihaylova; Annabelle Mery; Debbie S Vasquez; Benjamin E Turk; Reuben J Shaw
Journal:  Mol Cell       Date:  2008-04-25       Impact factor: 17.970

9.  Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates.

Authors:  Chang Z Chun; Sukhbir Kaur; Ganesh V Samant; Ling Wang; Kallal Pramanik; Maija K Garnaas; Keguo Li; Lyndsay Field; Debabrata Mukhopadhyay; Ramani Ramchandran
Journal:  Blood       Date:  2008-08-22       Impact factor: 22.113

10.  Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.

Authors:  Yujie Li; Yaohui Nie; Ynes Helou; Guoxian Ding; Bin Feng; Gang Xu; Arthur Salomon; Haiyan Xu
Journal:  Diabetes       Date:  2013-03-21       Impact factor: 9.461
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