| Literature DB >> 28719296 |
Anna Uehara1, Hasitha Aravinda Tissera2, Champica K Bodinayake3, Ananda Amarasinghe2, Ajith Nagahawatte3, L Gayani Tillekeratne4, Jie Cui5, Megan E Reller6, Paba Palihawadana2, Sunethra Gunasena7, Aruna Dharshan Desilva8, Annelies Wilder-Smith9,10, Duane J Gubler1, Christopher W Woods4, October M Sessions1.
Abstract
The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks since the 1960s, but since 1989 epidemics have become progressively larger and associated with more severe disease. The dominant virus in the 2012 epidemic was DENV-1, but DENV-4 infections were also commonly observed. DENV-4 transmission was first documented in Sri Lanka when it was isolated from a traveler in 1978, but has been comparatively uncommon since dengue surveillance began in the early 1980s. To better understand the molecular epidemiology of DENV-4 infections in Sri Lanka, we conducted whole-genome sequencing on dengue patient samples from two different geographic locations. Phylogenetic analysis indicates that all sequenced DENV-4 strains belong to genotype 1 and are most closely related to DENV-4 viruses previously found in Sri Lanka and those recently found to be circulating in India and Pakistan.Entities:
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Year: 2017 PMID： 28719296 PMCID： PMC5508889 DOI： 10.4269/ajtmh.16-0540
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345