Literature DB >> 28718447

Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?

Jianxiong Jiang1, Jiange Qiu2, Qianqian Li3, Zhi Shi4.   

Abstract

Elevated cyclooxygenase-2 (COX-2) and the associated inflammation within the brain contribute to glioblastoma development. However, medical use of COX inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE2) has emerged as a principal mediator for COX-2 cascade-driven gliomagenesis. Are PGE2 terminal synthases and receptors feasible therapeutic targets for glioblastoma?
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  EP receptors; PGE(2); glioblastoma; gliomagenesis; mPGES-1; neuroinflammation

Mesh：

Substances：

Year:  2017        PMID： 28718447      PMCID： PMC5518646          DOI： 10.1016/j.trecan.2016.12.002

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  16 in total

1.  The somatic genomic landscape of glioblastoma.

Authors:  Cameron W Brennan; Roel G W Verhaak; Aaron McKenna; Benito Campos; Houtan Noushmehr; Sofie R Salama; Siyuan Zheng; Debyani Chakravarty; J Zachary Sanborn; Samuel H Berman; Rameen Beroukhim; Brady Bernard; Chang-Jiun Wu; Giannicola Genovese; Ilya Shmulevich; Jill Barnholtz-Sloan; Lihua Zou; Rahulsimham Vegesna; Sachet A Shukla; Giovanni Ciriello; W K Yung; Wei Zhang; Carrie Sougnez; Tom Mikkelsen; Kenneth Aldape; Darell D Bigner; Erwin G Van Meir; Michael Prados; Andrew Sloan; Keith L Black; Jennifer Eschbacher; Gaetano Finocchiaro; William Friedman; David W Andrews; Abhijit Guha; Mary Iacocca; Brian P O'Neill; Greg Foltz; Jerome Myers; Daniel J Weisenberger; Robert Penny; Raju Kucherlapati; Charles M Perou; D Neil Hayes; Richard Gibbs; Marco Marra; Gordon B Mills; Eric Lander; Paul Spellman; Richard Wilson; Chris Sander; John Weinstein; Matthew Meyerson; Stacey Gabriel; Peter W Laird; David Haussler; Gad Getz; Lynda Chin
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

2.  Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.

Authors:  Troy Payner; H Anne Leaver; Brian Knapp; Ian R Whittle; Ovidiu C Trifan; Steven Miller; Maria Teresa Rizzo
Journal:  Mol Cancer Ther       Date:  2006-07       Impact factor: 6.261

Review 3.  Eicosanoids and cancer.

Authors:  Dingzhi Wang; Raymond N Dubois
Journal:  Nat Rev Cancer       Date:  2010-02-19       Impact factor: 60.716

Review 4.  Membrane prostaglandin E synthase-1: a novel therapeutic target.

Authors:  Bengt Samuelsson; Ralf Morgenstern; Per-Johan Jakobsson
Journal:  Pharmacol Rev       Date:  2007-09       Impact factor: 25.468

Review 5.  Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside.

Authors:  Avijit Dey; Xu Kang; Jiange Qiu; Yifeng Du; Jianxiong Jiang
Journal:  Trends Pharmacol Sci       Date:  2016-04-06       Impact factor: 14.819

6.  The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.

Authors:  Simo Mattila; Hannu Tuominen; John Koivukangas; Frej Stenbäck
Journal:  Neuropathology       Date:  2009-04       Impact factor: 1.906

7.  Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089.

Authors:  Muneaki Matsuo; Nobuyuki Yoshida; Masahumi Zaitsu; Kiyohisa Ishii; Yuhei Hamasaki
Journal:  J Neurooncol       Date:  2004-02       Impact factor: 4.130

8.  Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.

Authors:  Yoshiteru Nakano; Etsushi Kuroda; Tomohiro Kito; Satoshi Uematsu; Shizuo Akira; Akira Yokota; Shigeru Nishizawa; Uki Yamashita
Journal:  J Neurosurg       Date:  2008-02       Impact factor: 5.115

9.  Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.

Authors:  Jianxiong Jiang; Ray Dingledine
Journal:  J Pharmacol Exp Ther       Date:  2012-11-28       Impact factor: 4.030

10.  Radiation-induced PGE2 sustains human glioma cells growth and survival through EGF signaling.

Authors:  Emeline Brocard; Kristell Oizel; Lisenn Lalier; Claire Pecqueur; François Paris; François M Vallette; Lisa Oliver
Journal:  Oncotarget       Date:  2015-03-30
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  30 in total

1.  Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.

Authors:  Jiange Qiu; Qianqian Li; Katherine A Bell; Xue Yao; Yifeng Du; Erik Zhang; Jane J Yu; Ying Yu; Zhi Shi; Jianxiong Jiang
Journal:  Br J Pharmacol       Date:  2019-04-29       Impact factor: 8.739

2.  Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.

Authors:  Jianxiong Jiang; Ying Yu; Erika Reime Kinjo; Yifeng Du; Hoang Phuong Nguyen; Ray Dingledine
Journal:  Neuropharmacology       Date:  2019-02-11       Impact factor: 5.250

3.  Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2.

Authors:  Jianxiong Jiang; Tri Minh Van; Thota Ganesh; Raymond Dingledine
Journal:  ACS Chem Neurosci       Date:  2018-01-04       Impact factor: 4.418

Review 4.  G protein-coupled receptors in acquired epilepsy: Druggability and translatability.

Authors:  Ying Yu; Davis T Nguyen; Jianxiong Jiang
Journal:  Prog Neurobiol       Date:  2019-08-24       Impact factor: 11.685

5.  Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling.

Authors:  Subhendu Mukherjee; Wei Sheng; Alexander Michkov; Krishna Sriarm; Rui Sun; Anna Dvorkin-Gheva; Paul A Insel; Luke J Janssen
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2019-02-13       Impact factor: 5.464

6.  Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics.

Authors:  Ying Yu; Lexiao Li; Davis T Nguyen; Suni M Mustafa; Bob M Moore; Jianxiong Jiang
Journal:  Mol Neurobiol       Date:  2020-05-06       Impact factor: 5.590

Review 7.  PGE2 receptors in detrusor muscle: Drugging the undruggable for urgency.

Authors:  Ruida Hou; Ying Yu; Jianxiong Jiang
Journal:  Biochem Pharmacol       Date:  2020-12-09       Impact factor: 5.858

8.  Cyclooxygenase Inhibition Alters Proliferative, Migratory, and Invasive Properties of Human Glioblastoma Cells In Vitro.

Authors:  Matthew Thomas Ferreira; Juliano Andreoli Miyake; Renata Nascimento Gomes; Fábio Feitoza; Pollyana Bulgarelli Stevannato; Andrew Silva da Cunha; Fernanda de Oliveira Serachi; Alexandros Theodoros Panagopoulos; Alison Colquhoun
Journal:  Int J Mol Sci       Date:  2021-04-21       Impact factor: 5.923

Review 9.  Prostaglandin E receptors as targets for ischemic stroke: Novel evidence and molecular mechanisms of efficacy.

Authors:  Lexiao Li; Madison N Sluter; Ying Yu; Jianxiong Jiang
Journal:  Pharmacol Res       Date:  2020-10-11       Impact factor: 7.658

Review 10.  Small molecules targeting cyclooxygenase/prostanoid cascade in experimental brain ischemia: Do they translate?

Authors:  Jianxiong Jiang; Ying Yu
Journal:  Med Res Rev       Date:  2020-10-22       Impact factor: 12.944
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