| Literature DB >> 28716883 |
Timothy R Hercus1, Winnie L T Kan1, Sophie E Broughton2, Denis Tvorogov1, Hayley S Ramshaw1, Jarrod J Sandow3, Tracy L Nero2, Urmi Dhagat2, Emma J Thompson1, Karen S Cheung Tung Shing2,4, Duncan R McKenzie1, Nicholas J Wilson5, Catherine M Owczarek5, Gino Vairo5, Andrew D Nash5, Vinay Tergaonkar1,6, Timothy Hughes1,7, Paul G Ekert8, Michael S Samuel1,9, Claudine S Bonder1, Michele A Grimbaldeston1,10, Michael W Parker2,4, Angel F Lopez1.
Abstract
The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the βc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the βc cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.Entities:
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Year: 2018 PMID： 28716883 PMCID： PMC5983187 DOI： 10.1101/cshperspect.a028514
Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005