Literature DB >> 28711719

G protein-coupled receptor kinases: Past, present and future.

Konstantin E Komolov1, Jeffrey L Benovic2.   

Abstract

This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one of the authors trained with Bob in the 80s, we provide a history of work done in the Lefkowitz lab during the 80s that focused on dissecting the mechanisms that regulate GPCR signaling, with a particular emphasis on the GPCR kinases (GRKs). In addition, we highlight structure/function characteristics of GRK interaction with GPCRs as well as a review of two recent reports that provide a molecular model for GRK-GPCR interaction. Finally, we offer our perspective on some future studies that we believe will drive this field.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Arrestins; GPCR; GRK; Phosphorylation; Signaling; X-ray crystallography

Mesh：

Substances：

Year:  2017        PMID： 28711719      PMCID： PMC5722692          DOI： 10.1016/j.cellsig.2017.07.004

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


  97 in total

1.  Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.

Authors:  Ka Young Chung; Søren G F Rasmussen; Tong Liu; Sheng Li; Brian T DeVree; Pil Seok Chae; Diane Calinski; Brian K Kobilka; Virgil L Woods; Roger K Sunahara
Journal:  Nature       Date:  2011-09-28       Impact factor: 49.962

2.  Retinal S antigen identified as the 48K protein regulating light-dependent phosphodiesterase in rods.

Authors:  C Pfister; M Chabre; J Plouet; V V Tuyen; Y De Kozak; J P Faure; H Kühn
Journal:  Science       Date:  1985-05-17       Impact factor: 47.728

3.  Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.

Authors:  Kristoff T Homan; Helen V Waldschmidt; Alisa Glukhova; Alessandro Cannavo; Jianliang Song; Joseph Y Cheung; Walter J Koch; Scott D Larsen; John J G Tesmer
Journal:  J Biol Chem       Date:  2015-06-01       Impact factor: 5.157

4.  Can Specific Protein-Lipid Interactions Stabilize an Active State of the Beta 2 Adrenergic Receptor?

Authors:  Chris Neale; Henry D Herce; Régis Pomès; Angel E García
Journal:  Biophys J       Date:  2015-10-20       Impact factor: 4.033

5.  The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.

Authors:  David T Lodowski; Valerie M Tesmer; Jeffrey L Benovic; John J G Tesmer
Journal:  J Biol Chem       Date:  2006-04-13       Impact factor: 5.157

6.  G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling.

Authors:  Gurpreet K Dhami; Lianne B Dale; Pieter H Anborgh; Katharine E O'Connor-Halligan; Rachel Sterne-Marr; Stephen S G Ferguson
Journal:  J Biol Chem       Date:  2004-02-04       Impact factor: 5.157

7.  Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.

Authors:  Puja Singh; Benlian Wang; Tadao Maeda; Krzysztof Palczewski; John J G Tesmer
Journal:  J Biol Chem       Date:  2008-03-13       Impact factor: 5.157

8.  Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

Authors:  Helen V Waldschmidt; Kristoff T Homan; Marilyn C Cato; Osvaldo Cruz-Rodríguez; Alessandro Cannavo; Michael W Wilson; Jianliang Song; Joseph Y Cheung; Walter J Koch; John J G Tesmer; Scott D Larsen
Journal:  J Med Chem       Date:  2017-03-29       Impact factor: 7.446

9.  Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Authors:  Søren G F Rasmussen; Brian T DeVree; Yaozhong Zou; Andrew C Kruse; Ka Young Chung; Tong Sun Kobilka; Foon Sun Thian; Pil Seok Chae; Els Pardon; Diane Calinski; Jesper M Mathiesen; Syed T A Shah; Joseph A Lyons; Martin Caffrey; Samuel H Gellman; Jan Steyaert; Georgios Skiniotis; William I Weis; Roger K Sunahara; Brian K Kobilka
Journal:  Nature       Date:  2011-07-19       Impact factor: 49.962

10.  The origin and evolution of G protein-coupled receptor kinases.

Authors:  Arcady Mushegian; Vsevolod V Gurevich; Eugenia V Gurevich
Journal:  PLoS One       Date:  2012-03-19       Impact factor: 3.240
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  47 in total

Review 1.  Mechanistic diversity involved in the desensitization of G protein-coupled receptors.

Authors:  Ningning Sun; Kyeong-Man Kim
Journal:  Arch Pharm Res       Date:  2021-03-24       Impact factor: 4.946

Review 2.  Targeting G protein-coupled receptor signalling by blocking G proteins.

Authors:  Adrian P Campbell; Alan V Smrcka
Journal:  Nat Rev Drug Discov       Date:  2018-09-28       Impact factor: 84.694

3.  The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.

Authors:  Thomas F Pack; Margo I Orlen; Caroline Ray; Sean M Peterson; Marc G Caron
Journal:  J Biol Chem       Date:  2018-02-27       Impact factor: 5.157

Review 4.  Structure and dynamics of GPCR signaling complexes.

Authors:  Daniel Hilger; Matthieu Masureel; Brian K Kobilka
Journal:  Nat Struct Mol Biol       Date:  2018-01-08       Impact factor: 15.369

Review 5.  Dopamine: Functions, Signaling, and Association with Neurological Diseases.

Authors:  Marianne O Klein; Daniella S Battagello; Ariel R Cardoso; David N Hauser; Jackson C Bittencourt; Ricardo G Correa
Journal:  Cell Mol Neurobiol       Date:  2018-11-16       Impact factor: 5.046

Review 6.  The role of G protein-coupled receptor kinases in the pathology of malignant tumors.

Authors:  Wu-Yi Sun; Jing-Jing Wu; Wen-Ting Peng; Jia-Chang Sun; Wei Wei
Journal:  Acta Pharmacol Sin       Date:  2018-06-19       Impact factor: 6.150

7.  Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.

Authors:  Tyler S Beyett; Amy E Fraley; Emily Labudde; Dhabaleswar Patra; Ryan C Coleman; Akito Eguchi; Alisa Glukhova; Qiuyan Chen; Robert M Williams; Walter J Koch; David H Sherman; John J G Tesmer
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-23       Impact factor: 11.205

8.  Chemosensory signal transduction in Caenorhabditis elegans.

Authors:  Denise M Ferkey; Piali Sengupta; Noelle D L'Etoile
Journal:  Genetics       Date:  2021-03-31       Impact factor: 4.562

9.  Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli.

Authors:  Tyler S Beyett; Qiuyan Chen; Emily J Labudde; Joseph Krampen; Prateek V Sharma; John J G Tesmer
Journal:  Protein Expr Purif       Date:  2019-11-29       Impact factor: 1.650

10.  Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.

Authors:  Nestor N Jimenez-Vargas; Jing Gong; Matthew J Wisdom; Dane D Jensen; Rocco Latorre; Alan Hegron; Shavonne Teng; Jesse J DiCello; Pradeep Rajasekhar; Nicholas A Veldhuis; Simona E Carbone; Yang Yu; Cintya Lopez-Lopez; Josue Jaramillo-Polanco; Meritxell Canals; David E Reed; Alan E Lomax; Brian L Schmidt; Kam W Leong; Stephen J Vanner; Michelle L Halls; Nigel W Bunnett; Daniel P Poole
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-16       Impact factor: 11.205
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