Literature DB >> 29921886

The role of G protein-coupled receptor kinases in the pathology of malignant tumors.

Wu-Yi Sun1, Jing-Jing Wu1,2, Wen-Ting Peng1, Jia-Chang Sun1, Wei Wei3.   

Abstract

G protein-coupled receptor kinases (GRKs) constitute seven subtypes of serine/threonine protein kinases that specifically recognize and phosphorylate agonist-activated G protein-coupled receptors (GPCRs), thereby terminating the GPCRs-mediated signal transduction pathway. Recent research shows that GRKs also interact with non-GPCRs and participate in signal transduction in non-phosphorylated manner. Besides, GRKs activity can be regulated by multiple factors. Changes in GRKs expression have featured prominently in various tumor pathologies, and they are associated with angiogenesis, proliferation, migration, and invasion of malignant tumors. As a result, GRKs have been intensively studied as potential therapeutic targets. Herein, we review evolving understanding of the function of GRKs, the regulation of GRKs activity and the role of GRKs in human malignant tumor pathophysiology.

Entities:  

Keywords:  Breast cancer; G protein coupling receptor kinases; G protein-coupled receptors; Hepatocellular carcinoma; Lung cancer; Prostate cancer

Mesh：

Substances：

Year:  2018        PMID： 29921886      PMCID： PMC6289378          DOI： 10.1038/s41401-018-0049-z

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  71 in total

Review 1.  Phosphorylation-independent attenuation of GPCR signalling.

Authors:  Stephen S G Ferguson
Journal:  Trends Pharmacol Sci       Date:  2007-03-09       Impact factor: 14.819

2.  Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.

Authors:  Zhengyu Wei; Reginald Hurtt; Michele Ciccarelli; Walter J Koch; Cataldo Doria
Journal:  J Cell Physiol       Date:  2012-06       Impact factor: 6.384

3.  G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.

Authors:  Prabir Kumar Chakraborty; Yushan Zhang; Alexandra S Coomes; Wan-Ju Kim; Rachel Stupay; Lauren D Lynch; Tamieka Atkinson; Jae I Kim; Zhongzhen Nie; Yehia Daaka
Journal:  Cancer Res       Date:  2014-04-22       Impact factor: 12.701

4.  The influence of TNF-α and Ang II on the proliferation, migration and invasion of HepG2 cells by regulating the expression of GRK2.

Authors:  Zhou-Wei Xu; Shang-Xue Yan; Hua-Xun Wu; Jing-Yu Chen; Ying Zhang; Ying Li; Wei Wei
Journal:  Cancer Chemother Pharmacol       Date:  2017-03-18       Impact factor: 3.333

5.  Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.

Authors:  Katharina Deiss; Caroline Kisker; Martin J Lohse; Kristina Lorenz
Journal:  J Biol Chem       Date:  2012-05-17       Impact factor: 5.157

Review 6.  G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs.

Authors:  Laura Nogués; Julia Palacios-García; Clara Reglero; Verónica Rivas; María Neves; Catalina Ribas; Petronila Penela; Federico Mayor
Journal:  Semin Cancer Biol       Date:  2017-05-01       Impact factor: 15.707

7.  EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.

Authors:  Yuejun Chen; Hui Long; Ziyan Wu; Xi Jiang; Lan Ma
Journal:  Mol Biol Cell       Date:  2008-05-07       Impact factor: 4.138

8.  Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture.

Authors:  E Geras-Raaka; L Arvanitakis; C Bais; E Cesarman; E A Mesri; M C Gershengorn
Journal:  J Exp Med       Date:  1998-03-02       Impact factor: 14.307

9.  A multistep high-content screening approach to identify novel functionally relevant target genes in pancreatic cancer.

Authors:  Malte Buchholz; Tatjana Honstein; Sandra Kirchhoff; Ramona Kreider; Harald Schmidt; Bence Sipos; Thomas M Gress
Journal:  PLoS One       Date:  2015-04-07       Impact factor: 3.240

10.  Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.

Authors:  Liangping Yuan; Hongying Zhang; Jingbo Liu; Joshua B Rubin; Yoon-Jae Cho; Hui Kuo Shu; Matthew Schniederjan; Tobey J MacDonald
Journal:  Mol Cancer       Date:  2013-03-05       Impact factor: 27.401
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  7 in total

1.  GRK2 Suppresses Hepatocellular Carcinoma Metastasis and Invasion Through Down-Regulation of Prostaglandin E Receptor 2.

Authors:  Nan Li; Jing-Jing Wu; Ting-Ting Chen; Xiu-Qin Li; Jia-Jia Du; Shan Shan; Wei Wei; Wu-Yi Sun
Journal:  Onco Targets Ther       Date:  2020-09-28       Impact factor: 4.147

2.  G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma.

Authors:  Yunxiu Luo; Ziyi Wang; Shengjun Xiao; Ruirui Li; Xiaoshan Jiang
Journal:  Dis Markers       Date:  2022-06-20       Impact factor: 3.464

Review 3.  Differential Regulation of GPCRs-Are GRK Expression Levels the Key?

Authors:  Edda S F Matthees; Raphael S Haider; Carsten Hoffmann; Julia Drube
Journal:  Front Cell Dev Biol       Date:  2021-05-24

4.  Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H4 Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling.

Authors:  Eléonore W E Verweij; Betty Al Araaj; Wimzy R Prabhata; Rudi Prihandoko; Saskia Nijmeijer; Andrew B Tobin; Rob Leurs; Henry F Vischer
Journal:  ACS Pharmacol Transl Sci       Date:  2020-03-16

5.  CP-25 exerts anti-angiogenic effects on a rat model of adjuvant-induced arthritis by promoting GRK2-induced downregulation of CXCR4-ERK1/2 signaling in endothelial cells.

Authors:  Min Zhang; Mei Gao; Jinyu Chen; Lihua Song; Wei Wei
Journal:  Mol Med Rep       Date:  2019-10-23       Impact factor: 2.952

6.  Involvement of the Catecholamine Pathway in Glioblastoma Development.

Authors:  Zoltán Kraboth; Bela Kajtár; Bence Gálik; Attila Gyenesei; Attila Miseta; Bernadette Kalman
Journal:  Cells       Date:  2021-03-04       Impact factor: 6.600

Review 7.  G Protein-Coupled Receptor Kinase 2 as Novel Therapeutic Target in Fibrotic Diseases.

Authors:  Nan Li; Shan Shan; Xiu-Qin Li; Ting-Ting Chen; Meng Qi; Sheng-Nan Zhang; Zi-Ying Wang; Ling-Ling Zhang; Wei Wei; Wu-Yi Sun
Journal:  Front Immunol       Date:  2022-01-17       Impact factor: 7.561
  7 in total

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