Literature DB >> 2870914

Calcitonin gene-related peptide stimulates somatostatin release from isolated perfused rat stomach.

T Yamatani, S Kadowaki, T Chiba, H Abe, K Chihara, M Fukase, T Fujita.   

Abstract

Effect of calcitonin gene-related peptide (CGRP) on somatostatin release was investigated on the isolated perfused rat stomach. Perfusion with CGRP (0.1 nM-100 nM) caused a significant and dose-dependent increase in effluent somatostatin levels. The somatostatin response to CGRP was rapid in onset and reversible immediately after the cessation of CGRP infusion. These findings suggest that CGRP stimulates the release of gastric somatostatin, thereby modulating gastric functions in rat.

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Year:  1986        PMID： 2870914     DOI： 10.1210/endo-118-5-2144

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  7 in total

1.  The effects of capsaicin upon electrogenic ion transport in rat descending colon.

Authors:  S Yarrow; J A Ferrar; H M Cox
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-11       Impact factor: 3.000

2.  Intravenous calcitonin gene-related peptide stimulates net water secretion in rat colon in vivo.

Authors:  R K Rolston; M A Ghatei; P K Mulderry; S R Bloom
Journal:  Dig Dis Sci       Date:  1989-04       Impact factor: 3.199

3.  A role for calcitonin gene-related peptide in protection against gastric ulceration.

Authors:  J L Gray; N W Bunnett; S L Orloff; S J Mulvihill; H T Debas
Journal:  Ann Surg       Date:  1994-01       Impact factor: 12.969

4.  Effects of calcitonin gene-related peptide (CGRP) on islet hormone secretion in the pig.

Authors:  B Ahrén; H Mårtensson; A Nobin
Journal:  Diabetologia       Date:  1987-05       Impact factor: 10.122

5.  Calcitonin, as SMS 201-995, ameliorates the VIPoma syndrome.

Authors:  A Antonelli; C Gambuzza; F Bertoni; L Baschieri
Journal:  J Endocrinol Invest       Date:  1993-01       Impact factor: 4.256

6.  Effects of alpha- and beta-calcitonin gene-related peptides upon ion transport in rat descending colon.

Authors:  H M Cox; J A Ferrar; A W Cuthbert
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

7.  Calcitonin gene-related peptide: neuroendocrine communication between the pancreas, gut, and brain in regulation of blood glucose.

Authors:  Sayali A Pendharkar; Monika Walia; Marie Drury; Maxim S Petrov
Journal:  Ann Transl Med       Date:  2017-11
  7 in total

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