Literature DB >> 2790388

Effects of alpha- and beta-calcitonin gene-related peptides upon ion transport in rat descending colon.

H M Cox1, J A Ferrar, A W Cuthbert.   

Abstract

Both alpha- and beta-calcitonin gene-related peptide (CGRP) exhibit concentration-dependent dual actions upon rat colonic epithelia. At low concentrations (i.e. 0.03-10 nM) both CGRPs produce antisecretory effects that are abolished by pretreating tissues with tetrodotoxin (TTX). At higher concentrations (30-200 nM) secretory responses predominate and these effects are not abolished by TTX. It is suggested that the mediator of the antisecretory actions of CGRPs is somatostatin.

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Year:  1989        PMID： 2790388      PMCID： PMC1854645          DOI： 10.1111/j.1476-5381.1989.tb12553.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide.

Authors:  S G Amara; J L Arriza; S E Leff; L W Swanson; R M Evans; M G Rosenfeld
Journal:  Science       Date:  1985-09-13       Impact factor: 47.728

2.  Human alpha-calcitonin gene-related peptide influences colonic secretion by acting on myenteric neurons.

Authors:  C R McCulloch; H J Cooke
Journal:  Regul Pept       Date:  1989-01

3.  Projections of peptide-containing neurons in rat colon.

Authors:  E Ekblad; R Ekman; R Håkanson; F Sundler
Journal:  Neuroscience       Date:  1988-11       Impact factor: 3.590

4.  Kinins stimulate net chloride secretion by the rat colon.

Authors:  A W Cuthbert; H S Margolius
Journal:  Br J Pharmacol       Date:  1982-04       Impact factor: 8.739

5.  Calcitonin gene-related peptide: a potent and selective stimulator of gastrointestinal somatostatin secretion.

Authors:  B E Dunning; G J Taborsky
Journal:  Endocrinology       Date:  1987-05       Impact factor: 4.736

6.  Differential expression of alpha-CGRP and beta-CGRP by primary sensory neurons and enteric autonomic neurons of the rat.

Authors:  P K Mulderry; M A Ghatei; R A Spokes; P M Jones; A M Pierson; Q A Hamid; S Kanse; S G Amara; J M Burrin; S Legon
Journal:  Neuroscience       Date:  1988-04       Impact factor: 3.590

7.  Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing.

Authors:  M G Rosenfeld; J J Mermod; S G Amara; L W Swanson; P E Sawchenko; J Rivier; W W Vale; R M Evans
Journal:  Nature       Date:  1983 Jul 14-20       Impact factor: 49.962

8.  The effect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia.

Authors:  H M Cox; A W Cuthbert; R Håkanson; C Wahlestedt
Journal:  J Physiol       Date:  1988-04       Impact factor: 5.182

9.  Calcitonin gene-related peptide stimulates somatostatin release from isolated perfused rat stomach.

Authors:  T Yamatani; S Kadowaki; T Chiba; H Abe; K Chihara; M Fukase; T Fujita
Journal:  Endocrinology       Date:  1986-05       Impact factor: 4.736
  9 in total
  3 in total

1.  Localization of receptors for calcitonin-gene-related peptide to intraganglionic laminar endings of the mouse esophagus: peripheral interaction between vagal and spinal afferents?

Authors:  L Horling; N W Bunnett; K Messlinger; W L Neuhuber; M Raab
Journal:  Histochem Cell Biol       Date:  2013-11-08       Impact factor: 4.304

2.  The effects of capsaicin upon electrogenic ion transport in rat descending colon.

Authors:  S Yarrow; J A Ferrar; H M Cox
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-11       Impact factor: 3.000

3.  Calcitonin gene-related peptide receptors in human gastrointestinal epithelia.

Authors:  H M Cox; I R Tough
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739
  3 in total

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