Literature DB >> 28706379

Plasma level of Osteopontin does not respond to total replacement Surgery in patients with severe Primary knee/Hip Osteoarthritis.

Ramy Abdelnaby1, Sameh El Deeb1, Ali Khachab1, Klaus Bläsius1, Markus Tingart2, Björn Rath2.   

Abstract

OBJECTIVE: To test the response of Osteopontin levels in patients with knee/hip Osteoarthritis undergoing a replacement surgery.
METHOD: Plasma samples of 30 (16 with knee Osteoarthritis and 14 with hip Osteoarthritis) patients have been collected before and 3 month after a knee/hip replacement in order to investigate the above stated aim of this study. RESULT: Osteopontin levels did not decrease after 3 months of the surgery.
CONCLUSION: Osteopontin levels showed no significant reduction and therefore do not respond to replacement treatment.

Entities:  

Keywords:  Osteoarthritis OA; Osteopontin OPN; Total joint replacement surgery

Year:  2017        PMID： 28706379      PMCID： PMC5496198          DOI： 10.1016/j.jor.2017.06.008

Source DB:  PubMed          Journal:  J Orthop        ISSN： 0972-978X


  24 in total

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Authors:  J H KELLGREN; J S LAWRENCE
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Authors:  Hye-In Ji; Sang-Hoon Lee; Ran Song; Hyung-In Yang; Yeon-Ah Lee; Seung-Jae Hong; Somi Kim; Yong-Beom Park; Soo-Kon Lee; Myung Chul Yoo; Kyoung Soo Kim
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Authors:  Alisa E Koch
Journal:  Arthritis Rheum       Date:  2005-03

5.  The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation.

Authors:  Noriaki Mori; Tokifumi Majima; Norimasa Iwasaki; Shigeyuki Kon; Kiyoshi Miyakawa; Chiemi Kimura; Kunio Tanaka; David T Denhardt; Susan Rittling; Akio Minami; Toshimitsu Uede
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6.  Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype.

Authors:  Rieko Yagi; Denise McBurney; David Laverty; Scott Weiner; Walter E Horton
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7.  Signal transduction of mechanical stimuli is dependent on microfilament integrity: identification of osteopontin as a mechanically induced gene in osteoblasts.

Authors:  C D Toma; S Ashkar; M L Gray; J L Schaffer; L C Gerstenfeld
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Review 8.  Osteopontin: a bridge between bone and the immune system.

Authors:  Ellen M Gravallese
Journal:  J Clin Invest       Date:  2003-07       Impact factor: 14.808

9.  One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement.

Authors:  M Deberg; J-E Dubuc; A Labasse; C Sanchez; E Quettier; A Bosseloir; J-M Crielaard; Y Henrotin
Journal:  Ann Rheum Dis       Date:  2007-07-20       Impact factor: 19.103

Review 10.  The future of osteoarthritis therapeutics: emerging biological therapy.

Authors:  A Mobasheri
Journal:  Curr Rheumatol Rep       Date:  2013-12       Impact factor: 4.592
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