Sofia A Oluwole1, Kefeng Wang1, Chuanhui Dong1, Maria A Ciliberti-Vargas1, Carolina M Gutierrez1, Li Yi1, Jose G Romano1, Enmanuel Perez1, Brittany Ann Tyson1, Maranatha Ayodele1, Negar Asdaghi1, Hannah Gardener1, David Z Rose1, Enid J Garcia1, Juan Carlos Zevallos1, Dianne Foster1, Mary Robichaux1, Salina P Waddy1, Ralph L Sacco1, Tatjana Rundek2. 1. From the Department of Neurology, University of Miami Miller School of Medicine, FL (S.A.O., K.W., C.D., M.A.C.-V., C.M.G., L.Y., J.G.R., E.P., B.A.T., M.A., N.A., H.G., R.L.S., T.R.); Department of Neurology, University of South Florida Morsani College of Medicine, Tampa (D.Z.R.); National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (S.P.W.); The American Heart Association, Greater Southeast Affiliate, Marietta, GA (D.F., M.R.); and Florida International University Herbert Wertheim College of Medicine, Miami (J.C.Z) and University of Puerto Rico School of Medicine Endowed Health Services Research Center, San Juan (E.J.G.). 2. From the Department of Neurology, University of Miami Miller School of Medicine, FL (S.A.O., K.W., C.D., M.A.C.-V., C.M.G., L.Y., J.G.R., E.P., B.A.T., M.A., N.A., H.G., R.L.S., T.R.); Department of Neurology, University of South Florida Morsani College of Medicine, Tampa (D.Z.R.); National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (S.P.W.); The American Heart Association, Greater Southeast Affiliate, Marietta, GA (D.F., M.R.); and Florida International University Herbert Wertheim College of Medicine, Miami (J.C.Z) and University of Puerto Rico School of Medicine Endowed Health Services Research Center, San Juan (E.J.G.). TRundek@med.miami.edu.
Abstract
BACKGROUND AND PURPOSE: In the United States, about half of acute ischemic stroke patients treated with tPA (tissue-type plasminogen activator) receive treatment within 60 minutes of hospital arrival. We aimed to determine the proportion of patients receiving tPA within 60 minutes (door-to-needle time [DTNT] ≤60) and 45 minutes (DTNT ≤45) of hospital arrival by race/ethnicity and sex and to identify temporal trends in DTNT ≤60 and DTNT ≤45. METHODS: Among 65 654 acute ischemic stroke admissions in the National Institute of Neurological Disorders and Stroke-funded FL-PR CReSD study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities) from 2010 to 2015, we included 6181 intravenous tPA-treated cases (9.4%). Generalized estimating equations were used to determine predictors of DTNT ≤60 and DTNT ≤45. RESULTS: DTNT ≤60 was achieved in 42% and DTNT ≤45 in 18% of cases. After adjustment, women less likely received DTNT ≤60 (odds ratio, 0.81; 95% confidence interval, 0.72-0.92) and DTNT ≤45 (odds ratio, 0.73; 95% confidence interval, 0.57-0.93). Compared with Whites, Blacks less likely had DTNT ≤45 during off hours (odds ratio, 0.68; 95% confidence interval, 0.47-0.98). Achievement of DTNT ≤60 and DTNT ≤45 was highest in South Florida (50%, 23%) and lowest in West Central Florida (28%, 11%). CONCLUSIONS: In the FL-PR CReSD, achievement of DTNT ≤60 and DTNT ≤45 remains low. Compared with Whites, Blacks less likely receive tPA treatment within 45 minutes during off hours. Treatment within 60 and 45 minutes is lower in women compared with men and lowest in West Central Florida compared with other Florida regions and Puerto Rico. Further research is needed to identify reasons for delayed thrombolytic treatment in women and Blacks and factors contributing to regional disparities in DTNT.
BACKGROUND AND PURPOSE: In the United States, about half of acute ischemic strokepatients treated with tPA (tissue-type plasminogen activator) receive treatment within 60 minutes of hospital arrival. We aimed to determine the proportion of patients receiving tPA within 60 minutes (door-to-needle time [DTNT] ≤60) and 45 minutes (DTNT ≤45) of hospital arrival by race/ethnicity and sex and to identify temporal trends in DTNT ≤60 and DTNT ≤45. METHODS: Among 65 654 acute ischemic stroke admissions in the National Institute of Neurological Disorders and Stroke-funded FL-PR CReSD study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities) from 2010 to 2015, we included 6181 intravenous tPA-treated cases (9.4%). Generalized estimating equations were used to determine predictors of DTNT ≤60 and DTNT ≤45. RESULTS:DTNT ≤60 was achieved in 42% and DTNT ≤45 in 18% of cases. After adjustment, women less likely received DTNT ≤60 (odds ratio, 0.81; 95% confidence interval, 0.72-0.92) and DTNT ≤45 (odds ratio, 0.73; 95% confidence interval, 0.57-0.93). Compared with Whites, Blacks less likely had DTNT ≤45 during off hours (odds ratio, 0.68; 95% confidence interval, 0.47-0.98). Achievement of DTNT ≤60 and DTNT ≤45 was highest in South Florida (50%, 23%) and lowest in West Central Florida (28%, 11%). CONCLUSIONS: In the FL-PR CReSD, achievement of DTNT ≤60 and DTNT ≤45 remains low. Compared with Whites, Blacks less likely receive tPA treatment within 45 minutes during off hours. Treatment within 60 and 45 minutes is lower in women compared with men and lowest in West Central Florida compared with other Florida regions and Puerto Rico. Further research is needed to identify reasons for delayed thrombolytic treatment in women and Blacks and factors contributing to regional disparities in DTNT.
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