Marcelo José Uzeda1, Rodrigo Figueiredo de Brito Resende1, Suelen Cristina Sartoretto1, Adriana Terezinha Neves Novellino Alves2, José Mauro Granjeiro3,4, Mônica Diuana Calasans-Maia5. 1. Dentistry School, Postgraduate Program in Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. 2. Histology Department, Dentistry School, Postgraduate Program in Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. 3. Bioengineering Program, National Institute of Metrology, Quality and Technology, Duque de Caxias, Rio de Janeiro, Brazil. 4. Dentistry School, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. 5. Dental Clinical Research Center, Oral Surgery Department, Dentistry School, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
Abstract
BACKGROUND: The presence of nonresorbable residual granules of hydroxyapatite (HA) may decrease the bone/implant interface. To balance resorption and bone formation biphasic calcium phosphate ceramics compounds applied at different rates have been studied. PURPOSE: The aim of this trial was to compare the clinical, histological, and histomorphometric responses of two new biphasic calcium phosphate biomaterials in fresh dental sockets after 3 and 6 months. MATERIALS AND METHODS:Forty-eight volunteers were divided randomly and double-blindly into 4 groups of 12 individuals: Clot (C), BoneCeramic (BC), Biomaterial 1 (B1), and Biomaterial 2 (B2) groups. Three and six months later, samples were obtained, and histological and histomorphometric sections were evaluated, focusing on the presence of fibrous connective tissue (CT) and newly formed bone. Statistical analysis was performed (P < .05%). RESULTS: The quantification of crystalline phases showed B1 composed of HA (60.28%) and β-TCP (39.72%); B2 composed of HA (78.21%) and β-TCP (21.79%); and BC composed of HA (61%) and β-TCP (39%). The B1 group showed the most newly formed bone (69.3% ± 6.03%), followed by the BC (51.6 ± 12.34%), B2 (46.6 ± 7.66%), and C groups (45.4 ± 7.98%), and less connective tissue and biomaterial remained in the B1 group after 6 months. CONCLUSION: B1 group showed the greatest amount of newly formed bone after 6 months.
RCT Entities:
BACKGROUND: The presence of nonresorbable residual granules of hydroxyapatite (HA) may decrease the bone/implant interface. To balance resorption and bone formation biphasic calcium phosphate ceramics compounds applied at different rates have been studied. PURPOSE: The aim of this trial was to compare the clinical, histological, and histomorphometric responses of two new biphasic calcium phosphate biomaterials in fresh dental sockets after 3 and 6 months. MATERIALS AND METHODS: Forty-eight volunteers were divided randomly and double-blindly into 4 groups of 12 individuals: Clot (C), BoneCeramic (BC), Biomaterial 1 (B1), and Biomaterial 2 (B2) groups. Three and six months later, samples were obtained, and histological and histomorphometric sections were evaluated, focusing on the presence of fibrous connective tissue (CT) and newly formed bone. Statistical analysis was performed (P < .05%). RESULTS: The quantification of crystalline phases showed B1 composed of HA (60.28%) and β-TCP (39.72%); B2 composed of HA (78.21%) and β-TCP (21.79%); and BC composed of HA (61%) and β-TCP (39%). The B1 group showed the most newly formed bone (69.3% ± 6.03%), followed by the BC (51.6 ± 12.34%), B2 (46.6 ± 7.66%), and C groups (45.4 ± 7.98%), and less connective tissue and biomaterial remained in the B1 group after 6 months. CONCLUSION: B1 group showed the greatest amount of newly formed bone after 6 months.
Authors: L Canullo; M Del Fabbro; S Khijmatgar; S Panda; A Ravidà; G Tommasato; A Sculean; P Pesce Journal: Clin Oral Investig Date: 2021-11-26 Impact factor: 3.606
Authors: Jhonathan R B Nascimento; Suelen C Sartoretto; Adriana T N N Alves; Carlos F A B Mourão; Victor R Martinez-Zelaya; Marcelo J Uzeda; José M Granjeiro; Pietro Montemezzi; Monica D Calasans-Maia; José A Calasans-Maia Journal: Int J Environ Res Public Health Date: 2021-01-11 Impact factor: 3.390
Authors: Marija Čandrlić; Matej Tomas; Matej Karl; Lucija Malešić; Aleksandar Včev; Željka Perić Kačarević; Marko Matijević Journal: Int J Mol Sci Date: 2022-02-25 Impact factor: 5.923
Authors: S A Alkaabi; D S Natsir Kalla; G A Alsabri; A Fauzi; A Tajrin; W E G Müller; H C Schröder; X G Wang; T Forouzanfar; M N Helder; M Ruslin Journal: Trials Date: 2021-06-14 Impact factor: 2.279