Hongfang Wang1, Jinsheng Xu2, Demao Li3, Shenglei Zhang2, Zhanjun Guo4. 1. College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China. 2. Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. 3. Department of Thoracic Surgery, Xingtai People's Hospital, Xingtai, China. 4. Department of Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Abstract
BACKGROUND: Single nucleotide polymorphisms (SNPs) accumulated in the mitochondrial DNA (mtDNA) is susceptible to the tumor formation. We discovered previously that SNPs in the mitochondrial displacement loop (D-loop) was associated with the risk of hepatocellular carcinoma (HCC). METHODS: The cytochrome c oxidase (COX) genes of mtDNA were sequenced between 107 HCC patients and 100 matched healthy controls. The χ2 test was used to analyze single SNPs' statistical difference between HCC patients and healthy controls. RESULTS: In this study, cancer risk-associated SNPs in the COX genes of mtDNA coding region were assessed in HCC patients and health controls. The nucleotide position at site 9545A/G (P=.036) was identified its association for HCC with the 9545G allele susceptible to cancer risk. CONCLUSIONS: The SNPs in the COX genes may help us to evaluate the cancer risk of HCC.
BACKGROUND: Single nucleotide polymorphisms (SNPs) accumulated in the mitochondrial DNA (mtDNA) is susceptible to the tumor formation. We discovered previously that SNPs in the mitochondrial displacement loop (D-loop) was associated with the risk of hepatocellular carcinoma (HCC). METHODS: The cytochrome c oxidase (COX) genes of mtDNA were sequenced between 107 HCC patients and 100 matched healthy controls. The χ2 test was used to analyze single SNPs' statistical difference between HCC patients and healthy controls. RESULTS: In this study, cancer risk-associated SNPs in the COX genes of mtDNA coding region were assessed in HCC patients and health controls. The nucleotide position at site 9545A/G (P=.036) was identified its association for HCC with the 9545G allele susceptible to cancer risk. CONCLUSIONS: The SNPs in the COX genes may help us to evaluate the cancer risk of HCC.
Authors: Kyle P Feeley; Alexander W Bray; David G Westbrook; Larry W Johnson; Robert A Kesterson; Scott W Ballinger; Danny R Welch Journal: Cancer Res Date: 2015-10-15 Impact factor: 12.701
Authors: Maria Lueth; Lena Wronski; Almut Giese; Renate Kirschner-Schwabe; Torsten Pietsch; Andreas von Deimling; Guenter Henze; Andreas Kurtz; Pablo Hernáiz Driever Journal: Cancer Genet Cytogenet Date: 2009-07