Rationale for and results from a randomised, double-blind trial of tetrachlorodecaoxygen anion complex in wound healing.

Local tetrachlorodecaoxygen anion complex (TCDO) had three therapeutic effects in difficult wounds, substantiated on day 14 in a multicentre double-blind randomised clinical trial on 271 inpatients with 0.9% saline as control. Wound cleansing was intensified, the formation of new tissue (granulations, epithelium) was promoted, and, irrespective of the different wound types, wound surfaces decreased more quickly, by a factor of 2.4. A novel quantity (eta) was derived as an indicator of wound healing promotion. eta NaCl (= -0.14) did not differ among different wound diagnoses. eta TCDO values were significantly better in relation to wound diagnosis, to smear (detritus), and to epithelialisation. Local TCDO was well tolerated.

RCT Entities:   Population Interventions Outcomes