Literature DB >> 35008061

Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®).

Dirk Debus1, Semra Genç2, Philipp Kurz2, Martin Holzer3, Kurt Bauer3, Ralph Heimke-Brinck4, Martin Baier4, Heidi Sebald5, Andrea Debus5, Christian Bogdan5,6, Kurt-Wilhelm Stahl7.   

Abstract

Cutaneous leishmaniasis (CL) frequently entails chronic skin lesions that heal only slowly. Until now, the available therapeutic options are very limited. Here, we present a case of a 5½-year-old Syrian refugee with two progressive lower-leg skin ulcers caused by Leishmania tropica. The patient received topical treatment with LeiProtect®, a newly developed, hydroxypropylcellulose-based, filmogenic gel containing nontoxic concentrations of pharmaceutical sodium chlorite. The skin lesions completely healed within 8 weeks and did not relapse during 1 year of follow-up, underlining the efficacy of this novel local therapy of CL.

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Year:  2022        PMID: 35008061      PMCID: PMC8922486          DOI: 10.4269/ajtmh.21-0962

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   3.707


  14 in total

1.  Use of oral miltefosine for cutaneous leishmaniasis in Canadian soldiers returning from Afghanistan.

Authors:  Yoav Keynan; Oscar E Larios; Marni C Wiseman; Marie Plourde; Marc Ouellette; Ethan Rubinstein
Journal:  Can J Infect Dis Med Microbiol       Date:  2008-11       Impact factor: 2.471

2.  Leishmania tropica successfully treated with photodynamic therapy.

Authors:  Dana R-Ml Slape; Emma N-Y Kim; Paul Weller; Monisha Gupta
Journal:  Australas J Dermatol       Date:  2018-06-22       Impact factor: 2.875

Review 3.  Oxidative shielding or oxidative stress?

Authors:  Robert K Naviaux
Journal:  J Pharmacol Exp Ther       Date:  2012-06-13       Impact factor: 4.030

4.  Leishmania tropica in children: a retrospective study.

Authors:  Michal Solomon; Eli Schwartz; Felix Pavlotsky; Nicole Sakka; Aviv Barzilai; Shoshana Greenberger
Journal:  J Am Acad Dermatol       Date:  2014-04-26       Impact factor: 11.527

5.  Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis.

Authors:  A Asilian; A Sadeghinia; G Faghihi; A Momeni
Journal:  Int J Dermatol       Date:  2004-04       Impact factor: 2.736

6.  Travelers with cutaneous leishmaniasis cured without systemic therapy.

Authors:  G Morizot; E Kendjo; O Mouri; M Thellier; A Pérignon; F Foulet; F Cordoliani; E Bourrat; E Laffitte; I Alcaraz; N Bodak; C Ravel; M Vray; M Grogl; D Mazier; E Caumes; L Lachaud; P A Buffet
Journal:  Clin Infect Dis       Date:  2013-04-30       Impact factor: 9.079

7.  Ongoing epidemic of cutaneous leishmaniasis among Syrian refugees, Lebanon.

Authors:  Maya Saroufim; Khalil Charafeddine; Grace Issa; Haifaa Khalifeh; Robert H Habib; Atika Berry; Nada Ghosn; Alissar Rady; Ibrahim Khalifeh
Journal:  Emerg Infect Dis       Date:  2014-10       Impact factor: 6.883

8.  A randomized controlled phase IIb wound healing trial of cutaneous leishmaniasis ulcers with 0.045% pharmaceutical chlorite (DAC N-055) with and without bipolar high frequency electro-cauterization versus intralesional antimony in Afghanistan.

Authors:  Hans-Christian Stahl; Faridullah Ahmadi; Ulrike Schleicher; Rainer Sauerborn; Justo Lorenzo Bermejo; Mohammed Latif Amirih; Ibrahim Sakhayee; Christian Bogdan; Kurt-Wilhelm Stahl
Journal:  BMC Infect Dis       Date:  2014-11-25       Impact factor: 3.090

9.  Rhinophyma-Like Cutaneous Leishmaniasis due to Leishmania aethiopica Treated Successfully with Liposomal Amphotericin B.

Authors:  Michael Constantin Kirchberger; Stefan Schliep; Christian Bogdan
Journal:  Am J Trop Med Hyg       Date:  2019-02       Impact factor: 2.345

10.  Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase IIa trial in Kabul.

Authors:  Ahmad Fawad Jebran; Ulrike Schleicher; Reto Steiner; Pia Wentker; Farouq Mahfuz; Hans-Christian Stahl; Faquir Mohammad Amin; Christian Bogdan; Kurt-Wilhelm Stahl
Journal:  PLoS Negl Trop Dis       Date:  2014-02-13
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