| Literature DB >> 28701760 |
Carl Orr1, Elsa Vieira-Sousa2, David L Boyle3, Maya H Buch4, Christopher D Buckley5, Juan D Cañete6, Anca I Catrina7, Ernest H S Choy8, Paul Emery4, Ursula Fearon9, Andrew Filer5, Danielle Gerlag10,11, Frances Humby12, John D Isaacs13, Søren A Just14, Bernard R Lauwerys15, Benoit Le Goff16, Antonio Manzo17, Trudy McGarry9, Iain B McInnes18, Aurélie Najm16, Constantino Pitzalis12, Arthur Pratt13, Malcolm Smith19, Paul P Tak10,20, Rogier Thurlings21, João E Fonseca2, Douglas J Veale1, Sander W Tas10.
Abstract
The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.Entities:
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Year: 2017 PMID： 28701760 DOI： 10.1038/nrrheum.2017.115
Source DB: PubMed Journal: Nat Rev Rheumatol ISSN： 1759-4790 Impact factor: 20.543