Hanwen Liu1, Erin L MacMillian2, Catherine R Jutzeler2, Emil Ljungberg2, Alex L MacKay2, Shannon H Kolind2, Burkhard Mädler2, David K B Li2, Marcel F Dvorak2, Armin Curt2, Cornelia Laule2, John L K Kramer2. 1. From Physics and Astronomy (H.L., A.L.M., B.M.), ICORD (H.L., C.R.J., M.F.D., C.L., J.L.K.K.), Medicine (Neurology) (E.L.M., E.L., S.H.K., D.K.B.L.), Radiology (A.L.M., D.K.B.L., C.L.), Orthopaedics (M.F.D.), Pathology & Laboratory Medicine (C.L.), and School of Kinesiology (J.L.K.K.), University of British Columbia, Vancouver, Canada; Spinal Cord Injury Center (C.R.J., A.C.), University Hospital Balgrist, University of Zurich, Switzerland; and Philips Healthcare (B.M.), Hamburg, Germany. hanwen@phas.ubc.ca. 2. From Physics and Astronomy (H.L., A.L.M., B.M.), ICORD (H.L., C.R.J., M.F.D., C.L., J.L.K.K.), Medicine (Neurology) (E.L.M., E.L., S.H.K., D.K.B.L.), Radiology (A.L.M., D.K.B.L., C.L.), Orthopaedics (M.F.D.), Pathology & Laboratory Medicine (C.L.), and School of Kinesiology (J.L.K.K.), University of British Columbia, Vancouver, Canada; Spinal Cord Injury Center (C.R.J., A.C.), University Hospital Balgrist, University of Zurich, Switzerland; and Philips Healthcare (B.M.), Hamburg, Germany.
Abstract
PURPOSE: To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS: Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for the dorsal columns and whole cord. SSEPs and MWF were also compared with conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal cord compression (MSCC), and maximum canal compromise (MCC). RESULTS: Group analysis showed marked differences in T2 signal intensity, compression ratio, MSCC, and MCC between healthy controls and patients with CSM. There were no group differences in MWF and SSEP latencies. However, patients with CSM with pathologic SSEPs exhibited reduction in MWF (p < 0.05). MWF was also correlated with SSEP latencies. CONCLUSION: Our findings provide evidence of decreased myelin content in the spinal cord associated with impaired spinal cord conduction in patients with CSM. While conventional MRI are of great value to define the extent of cord compression, they show a limited correlation with functional deficits (i.e., delayed SSEPs). MWI provides independent and complementary readouts to spinal cord compression, with a high specificity to detect impaired conduction.
PURPOSE: To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS: Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for the dorsal columns and whole cord. SSEPs and MWF were also compared with conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal cord compression (MSCC), and maximum canal compromise (MCC). RESULTS: Group analysis showed marked differences in T2 signal intensity, compression ratio, MSCC, and MCC between healthy controls and patients with CSM. There were no group differences in MWF and SSEP latencies. However, patients with CSM with pathologic SSEPs exhibited reduction in MWF (p < 0.05). MWF was also correlated with SSEP latencies. CONCLUSION: Our findings provide evidence of decreased myelin content in the spinal cord associated with impaired spinal cord conduction in patients with CSM. While conventional MRI are of great value to define the extent of cord compression, they show a limited correlation with functional deficits (i.e., delayed SSEPs). MWI provides independent and complementary readouts to spinal cord compression, with a high specificity to detect impaired conduction.
Authors: Cornelia Laule; Andrew Yung; Vlady Pavolva; Barry Bohnet; Piotr Kozlowski; Stanley A Hashimoto; Stephen Yip; David Kb Li; Gr Wayne Moore Journal: Mult Scler Date: 2016-01-27 Impact factor: 6.312
Authors: Burkhard Mädler; Sylvia A Drabycz; Shannon H Kolind; Kenneth P Whittall; Alexander L MacKay Journal: Magn Reson Imaging Date: 2008-06-04 Impact factor: 2.546
Authors: Benjamin De Leener; Simon Lévy; Sara M Dupont; Vladimir S Fonov; Nikola Stikov; D Louis Collins; Virginie Callot; Julien Cohen-Adad Journal: Neuroimage Date: 2016-10-05 Impact factor: 6.556
Authors: Miloš Kerkovský; Josef Bednarík; Ladislav Dušek; Andrea Sprláková-Puková; Igor Urbánek; Marek Mechl; Vlastimil Válek; Zdenek Kadanka Journal: Spine (Phila Pa 1976) Date: 2012-01-01 Impact factor: 3.468
Authors: Carl Moritz Zipser; José Miguel Spirig; José Aguirre; Anna-Sophie Hofer; Nikolai Pfender; Markus Hupp; Armin Curt; Mazda Farshad; Martin Schubert Journal: Acta Neurochir Suppl Date: 2021
Authors: Jan Valošek; Petr Bednařík; Miloš Keřkovský; Petr Hluštík; Josef Bednařík; Alena Svatkova Journal: J Clin Med Date: 2022-04-20 Impact factor: 4.964
Authors: Jetan H Badhiwala; Christopher S Ahuja; Muhammad A Akbar; Christopher D Witiw; Farshad Nassiri; Julio C Furlan; Armin Curt; Jefferson R Wilson; Michael G Fehlings Journal: Nat Rev Neurol Date: 2020-01-23 Impact factor: 42.937
Authors: Zachary A Smith; Kenneth A Weber; Monica Paliwal; Benjamin S Hopkins; Alexander J Barry; Donald Cantrell; Aruna Ganju; Tyler R Koski; Todd B Parrish; Yasin Dhaher Journal: World Neurosurg Date: 2019-11-11 Impact factor: 2.104
Authors: Adam V Dvorak; Emil Ljungberg; Irene M Vavasour; Hanwen Liu; Poljanka Johnson; Alexander Rauscher; John L K Kramer; Roger Tam; David K B Li; Cornelia Laule; Laura Barlow; Hannah Briemberg; Alex L MacKay; Anthony Traboulsee; Piotr Kozlowski; Neil Cashman; Shannon H Kolind Journal: Neuroimage Clin Date: 2019-06-17 Impact factor: 4.881
Authors: Benjamin S Hopkins; Kenneth A Weber; Michael Brendan Cloney; Monica Paliwal; Todd B Parrish; Zachary A Smith Journal: Spine (Phila Pa 1976) Date: 2018-10-15 Impact factor: 3.241