Literature DB >> 28699004

A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor.

Francoise A Gourronc1, Larry W Robertson2, Aloysius J Klingelhutz3,4.   

Abstract

Inflammation in adipose tissue is recognized as a causative factor in the development of type II diabetes. Adipocyte hypertrophy as well as bacterial and environmental factors have been implicated in causing inflammation in mature adipocytes. Exposure to persistent organic pollutants such as polychlorinated biphenyls (PCBs) has been associated with the development of type II diabetes. We show here that PCB126, a dioxin-like PCB, activates a robust proinflammatory state in fat cell precursors (preadipocytes). The response was found to be dependent on aryl hydrocarbon receptor (AhR) activation, although induction of the response was delayed compared to upregulation of CYP1A1, a classic AhR-responsive gene. Treatment of preadipocytes with a nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) inhibitor partially attenuated the PCB126-induced inflammatory response and partly, but not completely, ameliorated disruption of adipogenesis caused by PCB126. Our results indicate a role for PCB126 in mediating an inflammatory response through AhR in preadipocytes that interferes with adipogenesis.

Entities:  

Keywords:  Adipocytes; AhR; Diabetes; Fat; Inflammation; PCB; Preadipocytes

Mesh：

Substances：

Year:  2017        PMID： 28699004      PMCID： PMC5764822          DOI： 10.1007/s11356-017-9676-z

Source DB:  PubMed          Journal:  Environ Sci Pollut Res Int        ISSN： 0944-1344            Impact factor:   4.223


  78 in total

1.  Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling.

Authors:  Ingrid Wernstedt Asterholm; Caroline Tao; Thomas S Morley; Qiong A Wang; Fernando Delgado-Lopez; Zhao V Wang; Philipp E Scherer
Journal:  Cell Metab       Date:  2014-06-12       Impact factor: 27.287

2.  Alteration by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of CCAAT/enhancer binding protein correlates with suppression of adipocyte differentiation in 3T3-L1 cells.

Authors:  P C Liu; M A Phillips; F Matsumura
Journal:  Mol Pharmacol       Date:  1996-06       Impact factor: 4.436

Review 3.  Inflammation and impaired adipogenesis in hypertrophic obesity in man.

Authors:  Birgit Gustafson; Silvia Gogg; Shahram Hedjazifar; Lachmi Jenndahl; Ann Hammarstedt; Ulf Smith
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-07-21       Impact factor: 4.310

4.  TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis.

Authors:  Melissa A Cimafranca; Paul R Hanlon; Colin R Jefcoate
Journal:  Toxicol Appl Pharmacol       Date:  2004-04-01       Impact factor: 4.219

Review 5.  Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Authors:  Adilson Guilherme; Joseph V Virbasius; Vishwajeet Puri; Michael P Czech
Journal:  Nat Rev Mol Cell Biol       Date:  2008-05       Impact factor: 94.444

6.  Serum PCB levels and congener profiles among teachers in PCB-containing schools: a pilot study.

Authors:  Robert F Herrick; John D Meeker; Larisa Altshul
Journal:  Environ Health       Date:  2011-06-13       Impact factor: 5.984

7.  Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.

Authors:  Min Ji Kim; Véronique Pelloux; Erwan Guyot; Joan Tordjman; Linh-Chi Bui; Aline Chevallier; Claude Forest; Chantal Benelli; Karine Clément; Robert Barouki
Journal:  Environ Health Perspect       Date:  2012-01-19       Impact factor: 9.031

8.  Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.

Authors:  Lily C Chao; Steven J Bensinger; Claudio J Villanueva; Kevin Wroblewski; Peter Tontonoz
Journal:  Mol Endocrinol       Date:  2008-10-22

9.  Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis.

Authors:  Violeta Arsenescu; Razvan I Arsenescu; Victoria King; Hollie Swanson; Lisa A Cassis
Journal:  Environ Health Perspect       Date:  2008-06       Impact factor: 9.031

10.  Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis.

Authors:  D L Alexander; L G Ganem; P Fernandez-Salguero; F Gonzalez; C R Jefcoate
Journal:  J Cell Sci       Date:  1998-11       Impact factor: 5.285
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  12 in total

1.  PCB 126 induces monocyte/macrophage polarization and inflammation through AhR and NF-κB pathways.

Authors:  Chunyan Wang; Michael C Petriello; Beibei Zhu; Bernhard Hennig
Journal:  Toxicol Appl Pharmacol       Date:  2019-02-13       Impact factor: 4.219

2.  Sex-specific effects of developmental exposure to polychlorinated biphenyls on neuroimmune and dopaminergic endpoints in adolescent rats.

Authors:  Deborah A Liberman; Katherine A Walker; Andrea C Gore; Margaret R Bell
Journal:  Neurotoxicol Teratol       Date:  2020-04-04       Impact factor: 3.763

3.  PCB126 blocks the thermogenic beiging response of adipocytes.

Authors:  Francoise A Gourronc; Gary H Perdew; Larry W Robertson; Aloysius J Klingelhutz
Journal:  Environ Sci Pollut Res Int       Date:  2019-11-12       Impact factor: 4.223

4.  Adipocytes are susceptible to Ebola Virus infection.

Authors:  Francoise A Gourronc; Michael R Rebagliati; Breanna Kramer-Riesberg; Anthony M Fleck; J J Patten; Kathleen Geohegan-Barek; Kelly N Messingham; Robert A Davey; Wendy Maury; Aloysius J Klingelhutz
Journal:  Virology       Date:  2022-05-27       Impact factor: 3.513

5.  Transcriptome sequencing of 3,3',4,4',5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes.

Authors:  Francoise A Gourronc; Brynn K Helm; Larry W Robertson; Michael S Chimenti; Hans Joachim-Lehmler; James A Ankrum; Aloysius J Klingelhutz
Journal:  Toxicol In Vitro       Date:  2022-05-23       Impact factor: 3.685

6.  Scaffold-free generation of uniform adipose spheroids for metabolism research and drug discovery.

Authors:  Aloysius J Klingelhutz; Francoise A Gourronc; Anna Chaly; David A Wadkins; Anthony J Burand; Kathleen R Markan; Sharon O Idiga; Meng Wu; Matthew J Potthoff; James A Ankrum
Journal:  Sci Rep       Date:  2018-01-11       Impact factor: 4.379

Review 7.  Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action.

Authors:  Nicole Mohajer; Chrislyn Y Du; Christian Checkcinco; Bruce Blumberg
Journal:  Front Endocrinol (Lausanne)       Date:  2021-11-25       Impact factor: 5.555

Review 8.  The Role of Persistent Organic Pollutants in Obesity: A Review of Laboratory and Epidemiological Studies.

Authors:  Jan Aaseth; Dragana Javorac; Aleksandra Buha Djordjevic; Zorica Bulat; Anatoly V Skalny; Irina P Zaitseva; Michael Aschner; Alexey A Tinkov
Journal:  Toxics       Date:  2022-02-02

9.  Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis.

Authors:  Francoise A Gourronc; Kathleen R Markan; Katarina Kulhankova; Zhiyong Zhu; Ryan Sheehy; Dawn E Quelle; Leonid V Zingman; Zoya B Kurago; James A Ankrum; Aloysius J Klingelhutz
Journal:  PLoS One       Date:  2020-07-30       Impact factor: 3.240

10.  Effects of PCB126 on Adipose-to-Muscle Communication in an in Vitro Model.

Authors:  Audrey Caron; Fozia Ahmed; Vian Peshdary; Léa Garneau; Ella Atlas; Céline Aguer
Journal:  Environ Health Perspect       Date:  2020-10-07       Impact factor: 9.031
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