Literature DB >> 28695889

Coding GPCR-G protein specificity.

Sebastian Gb Furness1, Patrick M Sexton1.   

Abstract

G protein-coupled receptors (GPCRs) are ubiquitous gatekeepers of cellular response and signal predominantly by recruitment and activation of G proteins. In a recent paper in Nature, Flock et al. use large-scale bioinformatics to build a model of GPCR-G protein selectivity and an interactive database to interrogate potential receptor-G protein interactions.

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Year:  2017        PMID： 28695889      PMCID： PMC5630685          DOI： 10.1038/cr.2017.92

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

Authors:  Sebastian George Barton Furness; Yi-Lynn Liang; Cameron James Nowell; Michelle Louise Halls; Peter John Wookey; Emma Dal Maso; Asuka Inoue; Arthur Christopoulos; Denise Wootten; Patrick Michael Sexton
Journal:  Cell       Date:  2016-10-06       Impact factor: 41.582

2.  Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha.

Authors:  B R Conklin; Z Farfel; K D Lustig; D Julius; H R Bourne
Journal:  Nature       Date:  1993-05-20       Impact factor: 49.962

3.  SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Authors:  Ron O Dror; Thomas J Mildorf; Daniel Hilger; Aashish Manglik; David W Borhani; Daniel H Arlow; Ansgar Philippsen; Nicolas Villanueva; Zhongyu Yang; Michael T Lerch; Wayne L Hubbell; Brian K Kobilka; Roger K Sunahara; David E Shaw
Journal:  Science       Date:  2015-06-19       Impact factor: 47.728

4.  Crystal structure of opsin in its G-protein-interacting conformation.

Authors:  Patrick Scheerer; Jung Hee Park; Peter W Hildebrand; Yong Ju Kim; Norbert Krauss; Hui-Woog Choe; Klaus Peter Hofmann; Oliver P Ernst
Journal:  Nature       Date:  2008-09-25       Impact factor: 49.962

5.  Selectivity determinants of GPCR-G-protein binding.

Authors:  Tilman Flock; Alexander S Hauser; Nadia Lund; David E Gloriam; Santhanam Balaji; M Madan Babu
Journal:  Nature       Date:  2017-05-10       Impact factor: 49.962

6.  Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Authors:  Søren G F Rasmussen; Brian T DeVree; Yaozhong Zou; Andrew C Kruse; Ka Young Chung; Tong Sun Kobilka; Foon Sun Thian; Pil Seok Chae; Els Pardon; Diane Calinski; Jesper M Mathiesen; Syed T A Shah; Joseph A Lyons; Martin Caffrey; Samuel H Gellman; Jan Steyaert; Georgios Skiniotis; William I Weis; Roger K Sunahara; Brian K Kobilka
Journal:  Nature       Date:  2011-07-19       Impact factor: 49.962

7.  Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.

Authors:  Yan Zhang; Bingfa Sun; Dan Feng; Hongli Hu; Matthew Chu; Qianhui Qu; Jeffrey T Tarrasch; Shane Li; Tong Sun Kobilka; Brian K Kobilka; Georgios Skiniotis
Journal:  Nature       Date:  2017-05-24       Impact factor: 49.962

8.  Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.

Authors:  G Glenn Gregorio; Matthieu Masureel; Daniel Hilger; Daniel S Terry; Manuel Juette; Hong Zhao; Zhou Zhou; Jose Manuel Perez-Aguilar; Maria Hauge; Signe Mathiasen; Jonathan A Javitch; Harel Weinstein; Brian K Kobilka; Scott C Blanchard
Journal:  Nature       Date:  2017-06-07       Impact factor: 49.962

9.  Structure of the adenosine A(2A) receptor bound to an engineered G protein.

Authors:  Byron Carpenter; Rony Nehmé; Tony Warne; Andrew G W Leslie; Christopher G Tate
Journal:  Nature       Date:  2016-07-27       Impact factor: 49.962

10.  Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Authors:  Yi-Lynn Liang; Maryam Khoshouei; Mazdak Radjainia; Yan Zhang; Alisa Glukhova; Jeffrey Tarrasch; David M Thal; Sebastian G B Furness; George Christopoulos; Thomas Coudrat; Radostin Danev; Wolfgang Baumeister; Laurence J Miller; Arthur Christopoulos; Brian K Kobilka; Denise Wootten; Georgios Skiniotis; Patrick M Sexton
Journal:  Nature       Date:  2017-04-24       Impact factor: 49.962
  10 in total

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