Jae-Uk Song1, Jiwon Hwang2, Joong Kyong Ahn3. 1. a Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine , Seoul , South Korea. 2. b Division of Rheumatology, Department of Internal Medicine , National Police Hospital , Seoul , South Korea. 3. c Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine , Seoul , South Korea.
Abstract
OBJECTIVES: To determine whether level of serum uric acid (SUA) is linked to pulmonary function in health screening examinees without overt medical conditions. METHODS: We performed a cross-sectional study on 69,928 Koreans that participated in an annual health check. RESULTS: Percent predicted forced vital capacity (FVC%) and forced expiratory volume in 1 s (FEV1%) were positively correlated with SUA in both genders (FVC%: r = .361; FEV1%: r = .314 in males and FVC%: r = .413; FEV1%: r = .382 in females, all p < .001). When the 2nd, 3rd and lowest FEV1% quartile were compared to the highest quartile group (the reference) by regression analysis, the adjusted ORs for hyperuricemia in males were 0.876 (95% CI, 0.809-0.949), 0.631 (0.574-0.695), and 0.311 (0.278-0.349), respectively. The adjusted ORs for hyperuricemia when the 2nd, 3rd and lowest FEV1% quartile were compared to the highest quartile in males were 0.791 (95% CI, 0.729-0.859), 0.565 (0.513-0.623), and 0.302 (0.270-0.337), respectively (p for trend <.001). Similarly, the adjusted OR of having hyperuricemia in females decreased significantly across FEV1% and FVC% quartile groups compared to the reference. CONCLUSIONS: Hyperuricemia may have a positive effect on pulmonary function in middle aged healthy population.
OBJECTIVES: To determine whether level of serum uric acid (SUA) is linked to pulmonary function in health screening examinees without overt medical conditions. METHODS: We performed a cross-sectional study on 69,928 Koreans that participated in an annual health check. RESULTS: Percent predicted forced vital capacity (FVC%) and forced expiratory volume in 1 s (FEV1%) were positively correlated with SUA in both genders (FVC%: r = .361; FEV1%: r = .314 in males and FVC%: r = .413; FEV1%: r = .382 in females, all p < .001). When the 2nd, 3rd and lowest FEV1% quartile were compared to the highest quartile group (the reference) by regression analysis, the adjusted ORs for hyperuricemia in males were 0.876 (95% CI, 0.809-0.949), 0.631 (0.574-0.695), and 0.311 (0.278-0.349), respectively. The adjusted ORs for hyperuricemia when the 2nd, 3rd and lowest FEV1% quartile were compared to the highest quartile in males were 0.791 (95% CI, 0.729-0.859), 0.565 (0.513-0.623), and 0.302 (0.270-0.337), respectively (p for trend <.001). Similarly, the adjusted OR of having hyperuricemia in females decreased significantly across FEV1% and FVC% quartile groups compared to the reference. CONCLUSIONS:Hyperuricemia may have a positive effect on pulmonary function in middle aged healthy population.