Joanna Jurewicz1, Michał Radwan, Bartosz Wielgomas, Emila Dziewirska, Anetta Karwacka, Anna Klimowska, Paweł Kałużny, Paweł Radwan, Michał Bochenek, Wojciech Hanke. 1. Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland (Drs Jurewicz, Dziewirska, Kałużny, Hanke); Department of Gynecology and Reproduction, "Gameta" Hospital, Rzgów, Poland (Drs Radwan, Karwacka, Radwan); Department of Toxicology, Medical University of Gdańsk, Gdańsk, Poland (Drs Wielgomas, Klimowska); and Department of Biotechnology of Animal Reproduction, National Research Institute of Animal Production, Kraków-Balice, Poland (Dr Bochenek).
Abstract
OBJECTIVE: The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol]. METHODS: Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300 mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method. Participants were interviewed and also provided a semen, saliva, and blood samples. RESULTS: Urinary parabens concentrations were significantly associated with an increase in the percentage of sperm with abnormal morphology, in sperm with high DNA stainability and a decrease in the percentage of motility and testosterone level. CONCLUSIONS: This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.
OBJECTIVE: The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol]. METHODS: Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300 mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method. Participants were interviewed and also provided a semen, saliva, and blood samples. RESULTS: Urinary parabens concentrations were significantly associated with an increase in the percentage of sperm with abnormal morphology, in sperm with high DNA stainability and a decrease in the percentage of motility and testosterone level. CONCLUSIONS: This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.
Authors: Emila Dziewirska; Michał Radwan; Bartosz Wielgomas; Anna Klimowska; Paweł Radwan; Paweł Kałużny; Wojciech Hanke; Maciej Słodki; Joanna Jurewicz Journal: Am J Mens Health Date: 2018-12-10
Authors: Aditi Sharma; Josephine Mollier; Richard W K Brocklesby; Charlotte Caves; Channa N Jayasena; Suks Minhas Journal: Reprod Med Biol Date: 2020-04-14