| Literature DB >> 28690072 |
Isadora F G Sena1, Pedro H D M Prazeres1, Gabryella S P Santos1, Isabella T Borges1, Patrick O Azevedo1, Julia P Andreotti1, Viviani M Almeida1, Ana E Paiva1, Daniel A P Guerra1, Luiza Lousado1, Luanny Souto1, Akiva Mintz2, Alexander Birbrair3.
Abstract
Bone marrow fibrosis is a critical component of primary myelofibrosis in which normal bone marrow tissue and blood-forming cells are gradually replaced with scar tissue. The specific cellular and molecular mechanisms that cause bone marrow fibrosis are not understood. A recent study using state-of-the-art techniques, including in vivo lineage tracing, provides evidence that Gli1+ cells are the cells responsible for fibrotic disease in the bone marrow. Strikingly, genetic depletion of Gli1+ cells rescues bone marrow failure and abolishes myelofibrosis. This work introduces a new central cellular target for bone marrow fibrosis. The knowledge that emerges from this research will be important for the treatment of several malignant and nonmalignant disorders.Entities:
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Year: 2017 PMID： 28690072 PMCID： PMC6076853 DOI： 10.1016/j.exphem.2017.06.349
Source DB: PubMed Journal: Exp Hematol ISSN： 0301-472X Impact factor: 3.084