| Literature DB >> 28689272 |
Ratchaneevan Aeimlapa1,2, Narattaphol Charoenphandhu3,4,5, Panan Suntornsaratoon1,2, Kannikar Wongdee2,6, Wacharaporn Tiyasatkulkovit2,7, Kanchana Kengkoom8, Nateetip Krishnamra1,2.
Abstract
In type 2 diabetes mellitus (T2DM), the decreased bone strength is often associated with hyperglycemia and bone cell insulin resistance. Since T2DM is increasingly reported in young adults, it is not known whether the effect of T2DM on bone would be different in young adolescents and aging adults. Here, we found shorter femoral and tibial lengths in 7-month, but not 13-month, Goto-Kakizaki (GK) T2DM rats as compared to wild-type rats. Bone µCT analysis showed long-lasting impairment of both cortical and trabecular bones in GK rats. Although insulin treatment effectively improved hyperglycemia, it was not able to rescue trabecular BMD and cortical thickness in young adult GK rats. In conclusion, insulin treatment and alleviation of hyperglycemia did not increase BMD of osteopenic GK rats. It is likely that early prevention of insulin resistance should prevail over treatment of full-blown T2DM-related osteopathy.Entities:
Keywords: Blood glucose; Bone mineral density; Diabetes mellitus; Diabetic osteopathy; Goto-Kakizaki rats
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Year: 2017 PMID： 28689272 DOI： 10.1007/s12576-017-0558-4
Source DB: PubMed Journal: J Physiol Sci ISSN： 1880-6546 Impact factor: 2.781