| Literature DB >> 28686933 |
Alessandro Rossi1, Silvana Galderisi2, Paola Rocca3, Alessandro Bertolino4, Paola Rucci5, Dino Gibertoni5, Paolo Stratta1, Paola Bucci2, Armida Mucci2, Eugenio Aguglia6, Giovanni Amodeo7, Mario Amore8, Antonello Bellomo9, Roberto Brugnoli10, Grazia Caforio4, Bernardo Carpiniello11, Liliana Dell'Osso12, Fabio di Fabio13, Massimo di Giannantonio14, Carlo Marchesi15, Palmiero Monteleone16, Cristiana Montemagni3, Lucio Oldani17, Rita Roncone18, Emilio Sacchetti19, Paolo Santonastaso20, Alberto Siracusano21, Patrizia Zeppegno22, Mario Maj2.
Abstract
Depression in schizophrenia represents a challenge from a diagnostic, psychopathological and therapeutic perspective. The objective of this study is to test the hypothesis that resilience and self-stigma affect depression severity and to evaluate the strength of their relations in 921 patients with schizophrenia. A structural equation model was tested where depression is hypothesized as affected by resilience, internalized stigma, gender and negative symptoms, with the latter two variables used as exogenous covariates and the former two as mediators. The analysis reveals that low resilience, high negative symptoms, female gender were directly associated with depression severity, and internalized stigma acted only as a mediator between avolition and resilience, with similar magnitude. The cross-sectional study design and the variable selection limit the generalizability of the study results. The model supports a complex interaction between personal resources and negative symptoms in predicting depression in schizophrenia. The clinical implication of these findings is that personal resources could be a significant target of psychosocial treatments.Entities:
Mesh：
Year: 2017 PMID： 28686933 DOI： 10.1016/j.psychres.2017.06.079
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222