L Shi1, F Gao2,3, W Sun4,5, B Wang2, W Guo2, L Cheng2, Z Li2, W Wang2. 1. Department of Orthopedics, Peking University China-Japan Friendship School of Clinical Medicine, 2 Yinghuadong Road, Chaoyang District, Beijing, 100029, China. 2. Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedic Surgery, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing, 100029, China. 3. Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing, 100029, China. 4. Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedic Surgery, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing, 100029, China. 18901267995@163.com. 5. Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing, 100029, China. 18901267995@163.com.
Abstract
It has been proved that extracorporeal shock wave therapy (ESWT) could promote new bone formation. Therefore, we designed an experiment to test the efficiency of ESWT on BMD in postmenopausal osteoporotic patients. The results showed that ESWT could effectively improve the local bone mass of the treated bone area within a short duration. INTRODUCTION: This study evaluated the short-term effectiveness of extracorporeal shock wave therapy (ESWT) on bone mineral density (BMD). METHODS: A total of 64 postmenopausal osteoporotic patients were recruited and randomized into 3 groups in 2015. Groups A (n = 20) and B (n = 21) patients received a single-session of low- or high-energy flux density (EFD) ESWT in the left hip, respectively, whereas group C (n = 23) patients served as controls without the ESWT treatment. All patients self-administered alendronate sodium tablets orally for a year. The BMD of the lumbar spine (L2-L4), femoral neck, great tuberosity, and total left hip was measured before ESWT treatment and at 3, 6, and 12 months using dual energy X-ray absorptiometry (DEXA). RESULTS: At 12 months, the lumbar spine, femoral neck, great tuberosity, and total left hip BMD in all patients had increased (p < 0.01). The increase in lumbar spine BMD in group A patients was higher than that in group B patients (p = 0.03); other between-group differences were not observed (p = 0.73, group A vs. C; p = 0.06, group B vs. C). The femoral neck, great tuberosity, and total left hip BMD increases in group B patients were higher than that in either group A or C (p < 0.01, group B vs. A; p < 0.01, group A vs. C). CONCLUSION: This study showed that ESWT could efficiently improve the local BMD; relatively, the high dosage was effective.
RCT Entities:
It has been proved that extracorporeal shock wave therapy (ESWT) could promote new bone formation. Therefore, we designed an experiment to test the efficiency of ESWT on BMD in postmenopausal osteoporoticpatients. The results showed that ESWT could effectively improve the local bone mass of the treated bone area within a short duration. INTRODUCTION: This study evaluated the short-term effectiveness of extracorporeal shock wave therapy (ESWT) on bone mineral density (BMD). METHODS: A total of 64 postmenopausal osteoporoticpatients were recruited and randomized into 3 groups in 2015. Groups A (n = 20) and B (n = 21) patients received a single-session of low- or high-energy flux density (EFD) ESWT in the left hip, respectively, whereas group C (n = 23) patients served as controls without the ESWT treatment. All patients self-administered alendronate sodium tablets orally for a year. The BMD of the lumbar spine (L2-L4), femoral neck, great tuberosity, and total left hip was measured before ESWT treatment and at 3, 6, and 12 months using dual energy X-ray absorptiometry (DEXA). RESULTS: At 12 months, the lumbar spine, femoral neck, great tuberosity, and total left hip BMD in all patients had increased (p < 0.01). The increase in lumbar spine BMD in group A patients was higher than that in group B patients (p = 0.03); other between-group differences were not observed (p = 0.73, group A vs. C; p = 0.06, group B vs. C). The femoral neck, great tuberosity, and total left hip BMD increases in group B patients were higher than that in either group A or C (p < 0.01, group B vs. A; p < 0.01, group A vs. C). CONCLUSION: This study showed that ESWT could efficiently improve the local BMD; relatively, the high dosage was effective.
Entities:
Keywords:
Bone mineral density; Extracorporeal shock wave therapy; Osteoporosis; Postmenopausal
Authors: M C D Agostino; R Frairia; P Romeo; E Amelio; L Berta; V Bosco; S Gigliotti; C Guerra; S Messina; L Messuri; B Moretti; A Notarnicola; G Maccagnano; S Russo; R Saggini; M C Vulpiani; P Buselli Journal: J Biol Regul Homeost Agents Date: 2016 Apr-Jun Impact factor: 1.711
Authors: S R Cummings; D M Black; M C Nevitt; W Browner; J Cauley; K Ensrud; H K Genant; L Palermo; J Scott; T M Vogt Journal: Lancet Date: 1993-01-09 Impact factor: 79.321
Authors: Ludger Gerdesmeyer; Stefan Wagenpfeil; Michael Haake; Markus Maier; Markus Loew; Klaus Wörtler; Renee Lampe; Romain Seil; Gerhart Handle; Susanne Gassel; Jan D Rompe Journal: JAMA Date: 2003-11-19 Impact factor: 56.272
Authors: Phimon Atsawasuwan; Yinghua Chen; Karan Ganjawalla; Albert L Kelling; Carla A Evans Journal: Head Face Med Date: 2018-11-12 Impact factor: 2.151
Authors: Marianne K E Koolen; Moyo C Kruyt; Fetullah C Öner; Wolfgang Schaden; Harrie Weinans; Olav P van der Jagt Journal: Arch Osteoporos Date: 2019-11-26 Impact factor: 2.617
Authors: F M Conesa-Buendía; A Mediero; R Fujikawa; P Esbrit; F Mulero; I Mahillo-Fernández; Arantxa Ortega-De Mues Journal: Sci Rep Date: 2020-08-06 Impact factor: 4.379