Early treatment events and prediction of response to neuroleptics in schizophrenia.

Events that occur early in the course of neuroleptic drug therapy in schizophrenia and which may be useful in predicting clinical outcome were investigated. Early subjective response and symptom change at twenty-four and forty-eight hours following initiation of drug therapy with either CPZ or haloperidol were the only variables that significantly related to therapeutic outcome. These preliminary results replicate and confirm previous results and provide a tool which can be included with other available approaches in developing a battery for prediction of drug response.