Daniel J Puleston1, Matteo Villa2, Erika L Pearce3. 1. Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, Freiburg 79108, Germany; Nuffield Department of Orthopedics, Rheumatology, and Musculoskeletal Diseases, The Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, UK. 2. Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, Freiburg 79108, Germany. 3. Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, Freiburg 79108, Germany. Electronic address: pearce@ie-freiburg.mpg.de.
Abstract
Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is less well understood. Here we survey the literature and highlight recent advances in our understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity.
Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core n class="Chemical">metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is less well understood. Here we survey the literature and highlight recent advances in our understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity.
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