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Literature DB >> 28679664

A cell-based mechanical model of coronary artery tunica media.

N B Melnikova^1,2, A I Svitenkov³, D R Hose⁴, A G Hoekstra^3,5.

Abstract

A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal close-packed lattice. Tissue anisotropy is taken into account by varying interaction forces with the direction of intercellular connection. Several cell-centre interaction potentials for repulsion and attraction are considered, including the Hertz contact model and its neo-Hookean extension, the Johnson-Kendall-Roberts model of adhesive contact, and a wormlike chain model. The model is validated against data from in vitro uni-axial tension tests performed on dissected strips of tunica media. The wormlike chain potential in combination with the neo-Hookean Hertz contact model produces stress-stretch curves which represent the experimental data very well.

Entities: Disease

Keywords: cell-based model; in silico stretch tests; mechanics; smooth muscle cell; tunica media

Mesh：

Year: 2017 PMID： 28679664 PMCID： PMC5550961 DOI： 10.1098/rsif.2017.0028

Source DB: PubMed Journal: J R Soc Interface ISSN： 1742-5662 Impact factor: 4.118

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A cell-based mechanical model of coronary artery tunica media.

1. A discrete mesoscopic particle model of the mechanics of a multi-constituent arterial wall.

2. Determination of layer-specific mechanical properties of human coronary arteries with nonatherosclerotic intimal thickening and related constitutive modeling.

Review 3. The virtual cell--a candidate co-ordinator for 'middle-out' modelling of biological systems.

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1. A cell-based mechanical model of coronary artery tunica media.

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