Davide D'Antini1, Michela Rauseo2, Salvatore Grasso3, Lucia Mirabella2, Luigi Camporota4,5, Antonella Cotoia6, Savino Spadaro6, Alberto Fersini7, Rocco Petta2, Rosaria Menga2, Alberto Sciusco8, Michele Dambrosio2, Gilda Cinnella2. 1. Department of Anesthesia and Intensive Care, University of Foggia, Foggia, Italy - davide.dantini@unifg.it. 2. Department of Anesthesia and Intensive Care, University of Foggia, Foggia, Italy. 3. Department of Anesthesia and Intensive Care, University of Bari, Bari, Italy. 4. Asthma, Allergy and Lung Biology Division, King's College London, London, UK. 5. Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, King's Health Partners, London, UK. 6. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy. 7. Department of General Surgery, University of Foggia, Foggia, Italy. 8. Department of Intensive Care and Anesthesia, North Bristol NHS Trust, Bristol, UK.
Abstract
BACKGROUND: During laparoscopy, respiratory mechanics and gas exchange are impaired because of pneumoperitoneum and atelectasis formation. We applied an open lung approach (OLA) consisting in lung recruitment followed by a decremental positive-end expiratory pressure (PEEP) trial to identify the level of PEEP corresponding to the highest compliance of the respiratory system (best PEEP). Our hypothesis was that this approach would improve both lung mechanics and oxygenation without hemodynamic impairment. METHODS: We studied twenty patients undergoing laparoscopic cholecystectomy. We continuously recorded respiratory mechanics parameters throughout a decremental PEEP trial in order to identify the best PEEP level. Furthermore, lung and chest wall mechanics, respiratory and transpulmonary driving pressures (ΔP), gas exchange and hemodynamics were recorded at three time-points: 1) after pneumoperitoneum induction (TpreOLA); 2) after the application of the OLA (TpostOLA); 3) at the end of surgery, after abdominal deflation (Tend). RESULTS: The "best PEEP" level was 8.1±1.3 cmH2O (range 6 to 10 cmH2O), corresponding to the highest compliance of the respiratory system (CRS). This "best PEEP" level corresponded with lowest ΔPL. OLA increased the compliance of the lung and of the chest wall, and decreased ΔPRS and ΔPL. PaO2/FiO2 increased from 299±125 mmHg to 406±101 mmHg (P=0.04). Changes in respiratory mechanics, driving pressures and oxygenation were maintained until Tend. Hemodynamic parameters remained stable throughout the study period. CONCLUSIONS: In patients undergoing laparoscopic cholecystectomy, the OLA was suitable for bedside PEEP setting, improved lung mechanics and gas exchange without significant adverse hemodynamic effects.
BACKGROUND: During laparoscopy, respiratory mechanics and gas exchange are impaired because of pneumoperitoneum and atelectasis formation. We applied an open lung approach (OLA) consisting in lung recruitment followed by a decremental positive-end expiratory pressure (PEEP) trial to identify the level of PEEP corresponding to the highest compliance of the respiratory system (best PEEP). Our hypothesis was that this approach would improve both lung mechanics and oxygenation without hemodynamic impairment. METHODS: We studied twenty patients undergoing laparoscopic cholecystectomy. We continuously recorded respiratory mechanics parameters throughout a decremental PEEP trial in order to identify the best PEEP level. Furthermore, lung and chest wall mechanics, respiratory and transpulmonary driving pressures (ΔP), gas exchange and hemodynamics were recorded at three time-points: 1) after pneumoperitoneum induction (TpreOLA); 2) after the application of the OLA (TpostOLA); 3) at the end of surgery, after abdominal deflation (Tend). RESULTS: The "best PEEP" level was 8.1±1.3 cmH2O (range 6 to 10 cmH2O), corresponding to the highest compliance of the respiratory system (CRS). This "best PEEP" level corresponded with lowest ΔPL. OLA increased the compliance of the lung and of the chest wall, and decreased ΔPRS and ΔPL. PaO2/FiO2 increased from 299±125 mmHg to 406±101 mmHg (P=0.04). Changes in respiratory mechanics, driving pressures and oxygenation were maintained until Tend. Hemodynamic parameters remained stable throughout the study period. CONCLUSIONS: In patients undergoing laparoscopic cholecystectomy, the OLA was suitable for bedside PEEP setting, improved lung mechanics and gas exchange without significant adverse hemodynamic effects.
Authors: Oscar Diaz-Cambronero; Blas Flor Lorente; Guido Mazzinari; Maria Vila Montañes; Nuria García Gregorio; Daniel Robles Hernandez; Luis Enrique Olmedilla Arnal; Maria Pilar Argente Navarro; Marcus J Schultz; Carlos L Errando Journal: Surg Endosc Date: 2018-06-27 Impact factor: 4.584
Authors: Guido Mazzinari; Ary Serpa Neto; Sabrine N T Hemmes; Goran Hedenstierna; Samir Jaber; Michael Hiesmayr; Markus W Hollmann; Gary H Mills; Marcos F Vidal Melo; Rupert M Pearse; Christian Putensen; Werner Schmid; Paolo Severgnini; Hermann Wrigge; Oscar Diaz Cambronero; Lorenzo Ball; Marcelo Gama de Abreu; Paolo Pelosi; Marcus J Schultz Journal: BMC Anesthesiol Date: 2021-03-19 Impact factor: 2.217
Authors: Caterina Di Bella; Caterina Vicenti; Joaquin Araos; Luca Lacitignola; Laura Fracassi; Marzia Stabile; Salvatore Grasso; Alberto Crovace; Francesco Staffieri Journal: Front Vet Sci Date: 2022-08-18