BACKGROUND: The oxygen (O2 ) pulse curve obtained at cardiopulmonary exercise testing provides information on cardiorespiratory fitness and the presence of cardiovascular disease. O2 pulse abnormalities have been attributed to myocardial ischemia, among other conditions, but the predictors of abnormal O2 pulse curves are not completely known. HYPOTHESIS: Perfusion abnormalities detected by myocardial perfusion scintigraphy (MPS) may be associated with abnormal O2 pulse curves. METHODS: Forty patients with normal left ventricular function underwent cardiopulmonary exercise testing with radiotracer injection at peak exercise, followed by MPS. The O2 pulse curves were classified as (A) normal; (B) probably normal (normal slope with lower peak value); (C) probably abnormal (flat, with low peak value); or (D) definitely abnormal (descending slope), and analyzed as A/B vs C/D. Coronary artery disease (CAD) was defined as >50% stenosis. MPS perfusion scores were calculated (summed rest score [SRS], indicating myocardial fibrosis; summed difference score, indicating ischemia). RESULTS: Comparing patients with A/B vs C/D curves, the latter were more frequently female and had higher SRS. The prevalence of ischemic MPS, of any CAD, or multivessel CAD was not significantly different among patients with A/B or C/D curve patterns. On logistic regression, female sex, body mass index, and the SRS were significantly associated with C/D curves. CONCLUSIONS: Female sex, increasing body mass index, and myocardial fibrosis were significant predictors of abnormal O2 pulse curves. Myocardial ischemia and the presence and extent of CAD were not associated with the abnormal patterns of the O2 pulse curve.
BACKGROUND: The oxygen (O2 ) pulse curve obtained at cardiopulmonary exercise testing provides information on cardiorespiratory fitness and the presence of cardiovascular disease. O2 pulse abnormalities have been attributed to myocardial ischemia, among other conditions, but the predictors of abnormal O2 pulse curves are not completely known. HYPOTHESIS: Perfusion abnormalities detected by myocardial perfusion scintigraphy (MPS) may be associated with abnormal O2 pulse curves. METHODS: Forty patients with normal left ventricular function underwent cardiopulmonary exercise testing with radiotracer injection at peak exercise, followed by MPS. The O2 pulse curves were classified as (A) normal; (B) probably normal (normal slope with lower peak value); (C) probably abnormal (flat, with low peak value); or (D) definitely abnormal (descending slope), and analyzed as A/B vs C/D. Coronary artery disease (CAD) was defined as >50% stenosis. MPS perfusion scores were calculated (summed rest score [SRS], indicating myocardial fibrosis; summed difference score, indicating ischemia). RESULTS: Comparing patients with A/B vs C/D curves, the latter were more frequently female and had higher SRS. The prevalence of ischemic MPS, of any CAD, or multivessel CAD was not significantly different among patients with A/B or C/D curve patterns. On logistic regression, female sex, body mass index, and the SRS were significantly associated with C/D curves. CONCLUSIONS: Female sex, increasing body mass index, and myocardial fibrosis were significant predictors of abnormal O2 pulse curves. Myocardial ischemia and the presence and extent of CAD were not associated with the abnormal patterns of the O2 pulse curve.
Authors: Gary J Balady; Ross Arena; Kathy Sietsema; Jonathan Myers; Lola Coke; Gerald F Fletcher; Daniel Forman; Barry Franklin; Marco Guazzi; Martha Gulati; Steven J Keteyian; Carl J Lavie; Richard Macko; Donna Mancini; Richard V Milani Journal: Circulation Date: 2010-06-28 Impact factor: 29.690
Authors: J Maddahi; H Kiat; K F Van Train; F Prigent; J Friedman; E V Garcia; N Alazraki; E G DePuey; K Nichols; D S Berman Journal: Am J Cardiol Date: 1990-10-16 Impact factor: 2.778
Authors: Eva C Munhoz; Ricardo Hollanda; João P Vargas; Carmem W Silveira; Alberto L Lemos; Ruth M K Hollanda; Jorge P Ribeiro Journal: Med Sci Sports Exerc Date: 2007-08 Impact factor: 5.411
Authors: D S Berman; R Hachamovitch; H Kiat; I Cohen; J A Cabico; F P Wang; J D Friedman; G Germano; K Van Train; G A Diamond Journal: J Am Coll Cardiol Date: 1995-09 Impact factor: 24.094
Authors: F H Messerli; K Sundgaard-Riise; E D Reisin; G R Dreslinski; H O Ventura; W Oigman; E D Frohlich; F G Dunn Journal: Ann Intern Med Date: 1983-12 Impact factor: 25.391
Authors: Andrea De Lorenzo; Carlito Lessa da Silva; Fernando Cesar Castro Souza; Salvador Serra; Pablo Marino; Ronaldo Sl Lima Journal: Clin Cardiol Date: 2017-07-05 Impact factor: 2.882
Authors: Andrea De Lorenzo; Carlito Lessa da Silva; Fernando Cesar Castro Souza; Salvador Serra; Pablo Marino; Ronaldo Sl Lima Journal: Clin Cardiol Date: 2017-07-05 Impact factor: 2.882
Authors: Bradley J Petek; Timothy W Churchill; J Sawalla Guseh; Garrett Loomer; Sarah K Gustus; Gregory D Lewis; Rory B Weiner; Aaron L Baggish; Meagan M Wasfy Journal: Physiol Rep Date: 2021-11