Kari Luotola1,2, Terhi T Piltonen3, Johanna Puurunen3, Laure C Morin-Papunen3, Juha S Tapanainen1,3. 1. a Department of Obstetrics and Gynecology , University of Helsinki and Helsinki University Hospital , Helsinki , Finland. 2. b Heart and Lung Center, Cardiology , Helsinki University Hospital , Helsinki , Finland. 3. c Department of Obstetrics and Gynecology , Oulu University Hospital, University of Oulu and Medical Research Center and PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology) , Oulu , Finland.
Abstract
OBJECTIVE: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS). DESIGN AND METHODS: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6 months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS. RESULTS:Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p ≤ .042). Free androgen index (FAI) associated with ISIMatsuda independently of adiposity (p ≤ .025) but in the full model with waist circumference the association was insignificant. ISIMatsuda decreased with testosterone >1.2 nmol/l compared with lower levels at baseline (p = .043) and at six months (p = .003). Accordingly, 30-minute insulin levels were increased with moderately elevated testosterone independently of adiposity (p ≤ .046). Increased fasting glucose and AUC insulin associated with statin treatment independently of adiposity and the associations attenuated after adjusting for testosterone. CONCLUSIONS: Moderately elevated testosterone concentrations together with obesity-related inflammatory factors modify glucose homeostasis by increasing insulin resistance and early insulin secretion.
RCT Entities:
OBJECTIVE: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS). DESIGN AND METHODS: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6 months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS. RESULTS:Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p ≤ .042). Free androgen index (FAI) associated with ISIMatsuda independently of adiposity (p ≤ .025) but in the full model with waist circumference the association was insignificant. ISIMatsuda decreased with testosterone >1.2 nmol/l compared with lower levels at baseline (p = .043) and at six months (p = .003). Accordingly, 30-minute insulin levels were increased with moderately elevated testosterone independently of adiposity (p ≤ .046). Increased fasting glucose and AUC insulin associated with statin treatment independently of adiposity and the associations attenuated after adjusting for testosterone. CONCLUSIONS: Moderately elevated testosterone concentrations together with obesity-related inflammatory factors modify glucose homeostasis by increasing insulin resistance and early insulin secretion.
Authors: Balachandran Kumarendran; Michael W O'Reilly; Anuradhaa Subramanian; Dana Šumilo; Konstantinos Toulis; Krishna M Gokhale; Chandrika N Wijeratne; Arri Coomarasamy; Abd A Tahrani; Laurent Azoulay; Wiebke Arlt; Krishnarajah Nirantharakumar Journal: Diabetes Care Date: 2021-10-14 Impact factor: 19.112
Authors: Sanjiv Risal; Yu Pei; Haojiang Lu; Maria Manti; Romina Fornes; Han-Pin Pui; Zhiyi Zhao; Julie Massart; Claes Ohlsson; Eva Lindgren; Nicolas Crisosto; Manuel Maliqueo; Barbara Echiburú; Amanda Ladrón de Guevara; Teresa Sir-Petermann; Henrik Larsson; Mina A Rosenqvist; Carolyn E Cesta; Anna Benrick; Qiaolin Deng; Elisabet Stener-Victorin Journal: Nat Med Date: 2019-12-02 Impact factor: 53.440