Robert S Krouse1,2,3, Christopher S Wendel4, David O Garcia5, Marcia Grant6, Larissa K F Temple7, Scott B Going8, Mark C Hornbrook9, Joanna E Bulkley9, Carmit K McMullen9, Lisa J Herrinton10. 1. University of Pennsylvania School of Medicine, 4 Silverstein, 3400 Spruce St., Philadelphia, PA, 19104, USA. robert.krouse@va.gov. 2. Leonard Davis Institute of Health Economics, Philadelphia, PA, USA. robert.krouse@va.gov. 3. Cpl. Michael J. Crescenz VA Medical Center, 3900 Woodland Ave., Philadelphia, PA, 19104, USA. robert.krouse@va.gov. 4. University of Arizona College of Medicine, 1501 S, Campbell Ave., Tucson, AZ, 85724, USA. 5. University of Arizona College of Public Health, 1295 N, Martin Ave., Tucson, AZ, 85724, USA. 6. Division of Nursing Research and Education, City of Hope/Beckman Research Institute, 1500 East Duarte Road, Duarte, CA, 91010, USA. 7. Division of Colorectal Surgery, University of Rochester Medical Center, 601 Elmwood Ave., Box SURG, Rochester, NY, 14642, USA. 8. Department of Nutritional Sciences, University of Arizona College of Agriculture and Life Sciences, 1177 E, 4th Street Shantz Bldg., Rm 309, Tucson, AZ, 85721, USA. 9. Kaiser Permanente Center for Health Research, 3800 N, Interstate Ave., Portland, OR, 97227, USA. 10. Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA, 94612, USA.
Abstract
PURPOSE: Physical activity (PA) is positively associated with numerous health benefits among cancer survivors. This study examined insufficiently investigated relationships among PA, health-related quality of life (HRQOL), and bowel function (BF) in rectal cancer survivors. METHODS: RC survivors (n = 1063) ≥5 years from diagnosis in two Kaiser permanente regions were mailed a multidimensional survey to assess HRQOL and BF. PA was assessed by a modified Godin Leisure-Time Exercise Questionnaire. PA minutes were categorized into weighted categories based on guidelines: (1) not active (zero PA minutes); (2) insufficiently active (1-149 PA minutes); (3) meeting guidelines (150-299 PA minutes); and (4) above guidelines (≥300 PA minutes). Relationships of PA with HRQOL and BF were evaluated using multiple linear regression, stratified by sex and ostomy status for BF. Types of PA identified as helpful for BF and symptoms addressed were summarized. RESULTS: Response rate was 60.5%. Of 557 participants, 40% met or exceeded PA guidelines, 34% were not active, and 26% were insufficiently active. Aerobic activities, specifically walking and cycling, were most commonly reported to help BF. Higher PA was associated with better psychological wellbeing and multiple SF12 scales, worse BF scores in men with ostomies, and better BF scores in women. CONCLUSIONS: Meeting or exceeding PA guidelines was associated with higher HRQOL. Although the BF findings are exploratory, they suggest women may benefit from increased PA, whereas men with ostomies may face challenges that require more study. Identifying PA strategies that will lead to improved patient compliance and benefit are needed.
PURPOSE: Physical activity (PA) is positively associated with numerous health benefits among cancer survivors. This study examined insufficiently investigated relationships among PA, health-related quality of life (HRQOL), and bowel function (BF) in rectal cancer survivors. METHODS: RC survivors (n = 1063) ≥5 years from diagnosis in two Kaiser permanente regions were mailed a multidimensional survey to assess HRQOL and BF. PA was assessed by a modified Godin Leisure-Time Exercise Questionnaire. PA minutes were categorized into weighted categories based on guidelines: (1) not active (zero PA minutes); (2) insufficiently active (1-149 PA minutes); (3) meeting guidelines (150-299 PA minutes); and (4) above guidelines (≥300 PA minutes). Relationships of PA with HRQOL and BF were evaluated using multiple linear regression, stratified by sex and ostomy status for BF. Types of PA identified as helpful for BF and symptoms addressed were summarized. RESULTS: Response rate was 60.5%. Of 557 participants, 40% met or exceeded PA guidelines, 34% were not active, and 26% were insufficiently active. Aerobic activities, specifically walking and cycling, were most commonly reported to help BF. Higher PA was associated with better psychological wellbeing and multiple SF12 scales, worse BF scores in men with ostomies, and better BF scores in women. CONCLUSIONS: Meeting or exceeding PA guidelines was associated with higher HRQOL. Although the BF findings are exploratory, they suggest women may benefit from increased PA, whereas men with ostomies may face challenges that require more study. Identifying PA strategies that will lead to improved patient compliance and benefit are needed.
Authors: S N Blair; M Dowda; R R Pate; J Kronenfeld; H G Howe; G Parker; A Blair; F Fridinger Journal: Am J Epidemiol Date: 1991-02-01 Impact factor: 4.897
Authors: Antoinetta J M Beijers; Floortje Mols; Vivianne C G Tjan-Heijnen; Catharina G Faber; Lonneke V van de Poll-Franse; Gerard Vreugdenhil Journal: Acta Oncol Date: 2014-11-24 Impact factor: 4.089
Authors: Lisa J Herrinton; Andrea Altschuler; Carmit K McMullen; Joanna E Bulkley; Mark C Hornbrook; Virginia Sun; Christopher S Wendel; Marcia Grant; Carol M Baldwin; Wendy Demark-Wahnefried; Larissa K F Temple; Robert S Krouse Journal: CA Cancer J Clin Date: 2016-03-21 Impact factor: 508.702
Authors: Robert S Krouse; Marcia Grant; Christopher S Wendel; M Jane Mohler; Susan M Rawl; Carol M Baldwin; Stephen Joel Coons; Ruth McCorkle; Clifford Y Ko; C Max Schmidt Journal: Dis Colon Rectum Date: 2007-12 Impact factor: 4.585
Authors: Virginia Sun; Christopher S Wendel; Wendy Demark-Wahnefried; Marcia Grant; Carmit K McMullen; Joanna E Bulkley; Lisa J Herrinton; Mark C Hornbrook; Robert S Krouse Journal: Nutr Cancer Date: 2018-12-20 Impact factor: 2.900
Authors: Marianne Krogsgaard; Rune Martens Andersen; Anne K Danielsen; Thordis Thomsen; Tobias Wirenfeldt Klausen; Bo Marcel Christensen; Ismail Gögenur; Anders Vinther Journal: Support Care Cancer Date: 2021-08-03 Impact factor: 3.603
Authors: Julia Mo; Cynthia A Thomson; Virginia Sun; Christopher S Wendel; Mark C Hornbrook; Ronald S Weinstein; Elizabeth Ercolano; Marcia Grant; Zuleyha Cidav; Ruth C McCorkle; Robert S Krouse Journal: J Cancer Surviv Date: 2020-09-17 Impact factor: 4.062
Authors: Anne Asnong; André D'Hoore; Albert Wolthuis; Yves Van Molhem; Bart Van Geluwe; Annouschka Laenen; Nele Devoogdt; An De Groef; Tessa De Vrieze; Charlotte Van Calster; Inge Geraerts Journal: BMC Public Health Date: 2021-12-13 Impact factor: 3.295