Petra J van Houdt1, Harsh K Agarwal2,3, Laurens D van Buuren1, Stijn W T P J Heijmink4, Søren Haack5, Henk G van der Poel6, Ghazaleh Ghobadi1, Floris J Pos1, Johannes M Peeters7, Peter L Choyke3, Uulke A van der Heide1. 1. Department of Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, the Netherlands. 2. Philips Research NA, Cambridge, Massachusetts, USA. 3. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 4. Department of Radiology, the Netherlands Cancer Institute, Amsterdam, the Netherlands. 5. Department of Clinical Engineering, Aarhus University Hospital, Aarhus, Denmark. 6. Department of Urology, the Netherlands Cancer Institute, Amsterdam, the Netherlands. 7. Philips Healthcare, Best, the Netherlands.
Abstract
PURPOSE: To evaluate the performance of a multi-echo spin-echo sequence with k-t undersampling scheme (k-t T2 ) in prostate cancer. METHODS: Phantom experiments were performed at five systems to estimate the bias, short-term repeatability, and reproducibility across all systems expressed with the within-subject coefficient of variation (wCV). Monthly measurements were performed on two systems for long-term repeatability estimation. To evaluate clinical repeatability, two T2 maps (voxel size 0.8 × 0.8 × 3 mm3 ; 5 min) were acquired at separate visits on one system for 13 prostate cancer patients. Repeatability was assessed per patient in relation to spatial resolution. T2 values were compared for tumor, peripheral zone, and transition zone. RESULTS: Phantom measurements showed a small bias (median = -0.9 ms) and good short-term repeatability (median wCV = 0.5%). Long-term repeatability was 0.9 and 1.1% and reproducibility between systems was 1.7%. The median bias observed in patients was -1.1 ms. At voxel level, the median wCV was 15%, dropping to 4% for structures of 0.5 cm3 . The median tumor T2 values (79 ms) were significantly lower (P < 0.001) than in the peripheral zone (149 ms), but overlapped with the transition zone (91 ms). CONCLUSIONS: Reproducible T2 mapping of the prostate is feasible with good spatial resolution in a clinically reasonable scan time, allowing reliable measurement of T2 in structures as small as 0.5 cm3 . Magn Reson Med 79:1586-1594, 2018.
PURPOSE: To evaluate the performance of a multi-echo spin-echo sequence with k-t undersampling scheme (k-t T2 ) in prostate cancer. METHODS: Phantom experiments were performed at five systems to estimate the bias, short-term repeatability, and reproducibility across all systems expressed with the within-subject coefficient of variation (wCV). Monthly measurements were performed on two systems for long-term repeatability estimation. To evaluate clinical repeatability, two T2 maps (voxel size 0.8 × 0.8 × 3 mm3 ; 5 min) were acquired at separate visits on one system for 13 prostate cancerpatients. Repeatability was assessed per patient in relation to spatial resolution. T2 values were compared for tumor, peripheral zone, and transition zone. RESULTS: Phantom measurements showed a small bias (median = -0.9 ms) and good short-term repeatability (median wCV = 0.5%). Long-term repeatability was 0.9 and 1.1% and reproducibility between systems was 1.7%. The median bias observed in patients was -1.1 ms. At voxel level, the median wCV was 15%, dropping to 4% for structures of 0.5 cm3 . The median tumor T2 values (79 ms) were significantly lower (P < 0.001) than in the peripheral zone (149 ms), but overlapped with the transition zone (91 ms). CONCLUSIONS: Reproducible T2 mapping of the prostate is feasible with good spatial resolution in a clinically reasonable scan time, allowing reliable measurement of T2 in structures as small as 0.5 cm3 . Magn Reson Med 79:1586-1594, 2018.
Authors: A Hoang Dinh; R Souchon; C Melodelima; F Bratan; F Mège-Lechevallier; M Colombel; O Rouvière Journal: Diagn Interv Imaging Date: 2014-12-23 Impact factor: 4.026
Authors: Fernando I Yamauchi; Tobias Penzkofer; Andriy Fedorov; Fiona M Fennessy; Renxin Chu; Stephan E Maier; Clare M C Tempany; Robert V Mulkern; Lawrence P Panych Journal: Magn Reson Imaging Date: 2015-02-14 Impact factor: 2.546
Authors: Warren D Foltz; Supriya Chopra; Peter Chung; Andrew Bayley; Charles Catton; David Jaffray; Graham A Wright; Masoom A Haider; Cynthia Ménard Journal: Magn Reson Med Date: 2010-10 Impact factor: 4.668
Authors: Ernesto Staroswiecki; Kristin L Granlund; Marcus T Alley; Garry E Gold; Brian A Hargreaves Journal: Magn Reson Med Date: 2011-12-16 Impact factor: 4.668
Authors: Tobias Hepp; Laura Kalmbach; Manuel Kolb; Petros Martirosian; Tom Hilbert; Wolfgang M Thaiss; Mike Notohamiprodjo; Jens Bedke; Konstantin Nikolaou; Arnulf Stenzl; Stephan Kruck; Sascha Kaufmann Journal: World J Urol Date: 2022-03-31 Impact factor: 3.661
Authors: Ernst S Kooreman; Petra J van Houdt; Rick Keesman; Vivian W J van Pelt; Marlies E Nowee; Floris Pos; Karolina Sikorska; Andreas Wetscherek; Arndt-Christian Müller; Daniela Thorwarth; Alison C Tree; Uulke A van der Heide Journal: Front Oncol Date: 2021-08-13 Impact factor: 6.244
Authors: Marcel A van Schie; Petra J van Houdt; Ghazaleh Ghobadi; Floris J Pos; Iris Walraven; Hans C J de Boer; Cornelis A T van den Berg; Robert Jan Smeenk; Linda G W Kerkmeijer; Uulke A van der Heide Journal: Front Oncol Date: 2019-12-04 Impact factor: 6.244