Literature DB >> 28669576

Histone H2A Monoubiquitination in Neurodevelopmental Disorders.

Anshika Srivastava1, Brian McGrath2, Stephanie L Bielas3.   

Abstract

Covalent histone modifications play an essential role in gene regulation and cellular specification required for multicellular organism development. Monoubiquitination of histone H2A (H2AUb1) is a reversible transcriptionally repressive mark. Exchange of histone H2A monoubiquitination and deubiquitination reflects the succession of transcriptional profiles during development required to produce cellular diversity from pluripotent cells. Germ-line pathogenic variants in components of the H2AUb1 regulatory axis are being identified as the genetic basis of congenital neurodevelopmental disorders. Here, we review the human genetics findings coalescing on molecular mechanisms that alter the genome-wide distribution of this histone modification required for development.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Polycomb repression; histone monoubiquitination; neurodevelopment disorders; neurogenetics

Mesh：

Substances：

Year:  2017        PMID： 28669576      PMCID： PMC5562288          DOI： 10.1016/j.tig.2017.06.002

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  96 in total

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