Yaou Liu1,2,3,4, Yunyun Duan5, Jing Huang5, Zhuoqiong Ren5, Zheng Liu6, Huiqing Dong6, Florian Weiler7, Horst K Hahn7, Fu-Dong Shi8, Helmut Butzkueven9, Frederik Barkhof10,11, Kuncheng Li12,13. 1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of China. asiaeurope80@gmail.com. 2. Beijing Key Lab of MRI and Brain Informatics, Beijing, 100053, People's Republic of China. asiaeurope80@gmail.com. 3. Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, 1007 MB, The Netherlands. asiaeurope80@gmail.com. 4. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China. asiaeurope80@gmail.com. 5. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of China. 6. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of China. 7. Fraunhofer MEVIS, Institute for Medical Image Computing, Universitätsallee 29, Bremen, 28359, Germany. 8. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China. 9. Department of Medicine, University of Melbourne, Parkville, 3010, Australia. 10. Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, 1007 MB, The Netherlands. 11. Institutes of Neurology and Healthcare Engineering, UCL, London, UK. 12. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of China. kunchengli55@gmail.com. 13. Beijing Key Lab of MRI and Brain Informatics, Beijing, 100053, People's Republic of China. kunchengli55@gmail.com.
Abstract
OBJECTIVE: To investigate the longitudinal spinal cord and brain changes in neuromyelitis optica (NMO) and multiple sclerosis (MS) and their associations with disability progression. PATIENTS AND METHODS: We recruited 28 NMO, 22 MS, and 20 healthy controls (HC), who underwent both spinal cord and brain MRI at baseline. Twenty-five NMO and 20 MS completed 1-year follow-up. Baseline spinal cord and brain lesion loads, mean upper cervical cord area (MUCCA), brain, and thalamus volume and their changes during a 1-year follow-up were measured and compared between groups. All the measurements were also compared between progressive and non-progressive groups in NMO and MS. RESULTS: MUCCA decreased significantly during the 1-year follow-up in NMO not in MS. Percentage brain volume changes (PBVC) and thalamus volume changes in MS were significantly higher than NMO. MUCCA changes were significantly different between progressive and non-progressive groups in NMO, while baseline brain lesion volume and PBVC were associated with disability progression in MS. MUCCA changes during 1-year follow-up showed association with clinical disability in NMO. CONCLUSION: Spinal cord atrophy changes were associated with disability progression in NMO, while baseline brain lesion load and whole brain atrophy changes were related to disability progression in MS. KEY POINTS: • Spinal cord atrophy progression was observed in NMO. • Spinal cord atrophy changes were associated with disability progression in NMO. • Brain lesion and atrophy were related to disability progression in MS.
OBJECTIVE: To investigate the longitudinal spinal cord and brain changes in neuromyelitis optica (NMO) and multiple sclerosis (MS) and their associations with disability progression. PATIENTS AND METHODS: We recruited 28 NMO, 22 MS, and 20 healthy controls (HC), who underwent both spinal cord and brain MRI at baseline. Twenty-five NMO and 20 MS completed 1-year follow-up. Baseline spinal cord and brain lesion loads, mean upper cervical cord area (MUCCA), brain, and thalamus volume and their changes during a 1-year follow-up were measured and compared between groups. All the measurements were also compared between progressive and non-progressive groups in NMO and MS. RESULTS: MUCCA decreased significantly during the 1-year follow-up in NMO not in MS. Percentage brain volume changes (PBVC) and thalamus volume changes in MS were significantly higher than NMO. MUCCA changes were significantly different between progressive and non-progressive groups in NMO, while baseline brain lesion volume and PBVC were associated with disability progression in MS. MUCCA changes during 1-year follow-up showed association with clinical disability in NMO. CONCLUSION:Spinal cord atrophy changes were associated with disability progression in NMO, while baseline brain lesion load and whole brain atrophy changes were related to disability progression in MS. KEY POINTS: • Spinal cord atrophy progression was observed in NMO. • Spinal cord atrophy changes were associated with disability progression in NMO. • Brain lesion and atrophy were related to disability progression in MS.
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Menno M Schoonheim; Hanneke E Hulst; Roemer B Brandt; Myrte Strik; Alle Meije Wink; Bernard M J Uitdehaag; Frederik Barkhof; Jeroen J G Geurts Journal: Neurology Date: 2015-01-23 Impact factor: 9.910
Authors: Hugo Vrenken; Eline K Vos; W M van der Flier; Ingrid C Sluimer; Keith S Cover; Dirk L Knol; Frederik Barkhof Journal: Hum Brain Mapp Date: 2013-01-30 Impact factor: 5.038