Menno M Schoonheim1, Hanneke E Hulst2, Roemer B Brandt2, Myrte Strik2, Alle Meije Wink2, Bernard M J Uitdehaag2, Frederik Barkhof2, Jeroen J G Geurts2. 1. From the Department of Anatomy & Neurosciences (M.M.S., H.E.H., J.J.G.G.), Radiology and Nuclear Medicine (R.B.B., M.S., A.M.W., F.B.), and Neurology (B.M.J.U.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands. m.schoonheim@vumc.nl. 2. From the Department of Anatomy & Neurosciences (M.M.S., H.E.H., J.J.G.G.), Radiology and Nuclear Medicine (R.B.B., M.S., A.M.W., F.B.), and Neurology (B.M.J.U.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands.
Abstract
OBJECTIVE: This study investigates whether changes in functional connectivity, diffusivity, and volume of the thalamus can explain different severities of cognitive impairment in multiple sclerosis (MS). METHODS: An inception cohort of 157 patients with MS (104 women, mean age 41 years), 6 years postdiagnosis, was divided into 3 groups: cognitively preserved (CP, n = 108), mildly cognitively impaired (MCI, n = 22), and more severely cognitively impaired (SCI, n = 27). These groups were matched to 47 healthy controls (HC, 28 women, mean age 41 years). Thalamic volume, thalamic skeleton diffusivity (fractional anisotropy [FA] and mean diffusivity [MD]), and thalamic resting-state functional connectivity (FC) were compared between groups. RESULTS: Thalamic volume was significantly lower in all patient groups compared to controls, with lowest volumes in patients with SCI, and no difference between CP and MCI. Thalamic skeleton FA was decreased in SCI compared to HC only; MD was increased in SCI compared to all other groups. Thalamic FC was increased in SCI with a total of 15 regions, mainly sensorimotor, frontal, and occipital parts of the brain. Thalamic volume, FC, and MD remained independent predictors in a linear regression model (R(2) = 0.46), together with male sex and a lower level of education. Lesion and whole-brain volumes were not significant predictors. CONCLUSIONS: These findings indicate that thalamic changes in structure and function are highly informative regarding overall cognitive performance in MS. Increased thalamic FC only became apparent in SCI, possibly as a sign of maladaption.
OBJECTIVE: This study investigates whether changes in functional connectivity, diffusivity, and volume of the thalamus can explain different severities of cognitive impairment in multiple sclerosis (MS). METHODS: An inception cohort of 157 patients with MS (104 women, mean age 41 years), 6 years postdiagnosis, was divided into 3 groups: cognitively preserved (CP, n = 108), mildly cognitively impaired (MCI, n = 22), and more severely cognitively impaired (SCI, n = 27). These groups were matched to 47 healthy controls (HC, 28 women, mean age 41 years). Thalamic volume, thalamic skeleton diffusivity (fractional anisotropy [FA] and mean diffusivity [MD]), and thalamic resting-state functional connectivity (FC) were compared between groups. RESULTS: Thalamic volume was significantly lower in all patient groups compared to controls, with lowest volumes in patients with SCI, and no difference between CP and MCI. Thalamic skeleton FA was decreased in SCI compared to HC only; MD was increased in SCI compared to all other groups. Thalamic FC was increased in SCI with a total of 15 regions, mainly sensorimotor, frontal, and occipital parts of the brain. Thalamic volume, FC, and MD remained independent predictors in a linear regression model (R(2) = 0.46), together with male sex and a lower level of education. Lesion and whole-brain volumes were not significant predictors. CONCLUSIONS: These findings indicate that thalamic changes in structure and function are highly informative regarding overall cognitive performance in MS. Increased thalamic FC only became apparent in SCI, possibly as a sign of maladaption.
Authors: Christian Enzinger; Frederik Barkhof; Olga Ciccarelli; Massimo Filippi; Ludwig Kappos; Maria A Rocca; Stefan Ropele; Àlex Rovira; Torben Schneider; Nicola de Stefano; Hugo Vrenken; Claudia Wheeler-Kingshott; Jens Wuerfel; Franz Fazekas Journal: Nat Rev Neurol Date: 2015-11-03 Impact factor: 42.937
Authors: G Pontillo; S Cocozza; R Lanzillo; C Russo; M D Stasi; C Paolella; E A Vola; C Criscuolo; P Borrelli; G Palma; E Tedeschi; V B Morra; A Elefante; A Brunetti Journal: AJNR Am J Neuroradiol Date: 2018-12-20 Impact factor: 3.825
Authors: Katherine A Koenig; Stephen M Rao; Mark J Lowe; Jian Lin; Ken E Sakaie; Lael Stone; Robert A Bermel; Bruce D Trapp; Micheal D Phillips Journal: Mult Scler Date: 2018-03-07 Impact factor: 6.312
Authors: Alexandra van Wijnen; Franca Petrov; Michelle Maiworm; Stefan Frisch; Christian Foerch; Elke Hattingen; Helmuth Steinmetz; Johannes C Klein; Ralf Deichmann; Marlies Wagner; René-Maxime Gracien Journal: Eur Radiol Date: 2019-10-10 Impact factor: 5.315
Authors: Prejaas Tewarie; Menno M Schoonheim; Daphne I Schouten; Chris H Polman; Lisanne J Balk; Bernard M J Uitdehaag; Jeroen J G Geurts; Arjan Hillebrand; Frederik Barkhof; Cornelis J Stam Journal: Hum Brain Mapp Date: 2014-10-08 Impact factor: 5.038
Authors: D Damjanovic; P Valsasina; M A Rocca; M L Stromillo; A Gallo; C Enzinger; H E Hulst; A Rovira; N Muhlert; N De Stefano; A Bisecco; F Fazekas; M J Arévalo; T A Yousry; M Filippi Journal: AJNR Am J Neuroradiol Date: 2016-09-29 Impact factor: 3.825