M McCarron1, P McCallion2, E Reilly3, P Dunne3, R Carroll1, N Mulryan3. 1. School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland. 2. Center for Excellence in Aging & Community Wellness, University at Albany, Albany, NY, USA. 3. Daughters of Charity Disability Support Service, Dublin, Ireland.
Abstract
GOAL: To examine dementia characteristics, age at onset and associated co-morbidities in persons with Down syndrome. METHOD: A total of 77 people with Down syndrome aged 35 years and older were followed up from 1996 to 2015. The diagnosis of dementia was established using the modified ICD 10 Criteria and a combination of objective and informant-based tests. Cognitive tests included the Test for Severe Impairment and the Down Syndrome Mental Status Examination; adaptive behaviour was measured using the Daily Living Skills Questionnaire, and data from the Dementia Questionnaire for People with Intellectual Disabilities have been available since 2005. RESULTS: Over the 20-year period, 97.4% (75 of 77) persons developed dementia with a mean age of dementia diagnosis of 55 years (SD = 7.1, median = 56 years). Clinical dementia was associated with cognitive and function decline and seizure activity. Risk for dementia increased from 23% in those aged 50 years to 80% in those aged 65 years and above. There were no differences by level of ID. CONCLUSION: The previously reported high risk levels for dementia among people with Down syndrome were confirmed in this data as was the relationship with late onset epilepsy. The value of the instruments utilised in tracking decline and helping to confirm diagnosis is further highlighted.
GOAL: To examine dementia characteristics, age at onset and associated co-morbidities in persons with Down syndrome. METHOD: A total of 77 people with Down syndrome aged 35 years and older were followed up from 1996 to 2015. The diagnosis of dementia was established using the modified ICD 10 Criteria and a combination of objective and informant-based tests. Cognitive tests included the Test for Severe Impairment and the Down Syndrome Mental Status Examination; adaptive behaviour was measured using the Daily Living Skills Questionnaire, and data from the Dementia Questionnaire for People with Intellectual Disabilities have been available since 2005. RESULTS: Over the 20-year period, 97.4% (75 of 77) persons developed dementia with a mean age of dementia diagnosis of 55 years (SD = 7.1, median = 56 years). Clinical dementia was associated with cognitive and function decline and seizure activity. Risk for dementia increased from 23% in those aged 50 years to 80% in those aged 65 years and above. There were no differences by level of ID. CONCLUSION: The previously reported high risk levels for dementia among people with Down syndrome were confirmed in this data as was the relationship with late onset epilepsy. The value of the instruments utilised in tracking decline and helping to confirm diagnosis is further highlighted.
Authors: Michael S Rafii; Beau M Ances; Nicole Schupf; Sharon J Krinsky-McHale; Mark Mapstone; Wayne Silverman; Ira Lott; William Klunk; Elizabeth Head; Brad Christian; Florence Lai; H Diana Rosas; Shahid Zaman; Melissa E Petersen; Andre Strydom; Juan Fortea; Benjamin Handen; Sid O'Bryant Journal: Alzheimers Dement (Amst) Date: 2020-10-27
Authors: Ganesh M Babulal; Yakeel T Quiroz; Benedict C Albensi; Eider Arenaza-Urquijo; Arlene J Astell; Claudio Babiloni; Alex Bahar-Fuchs; Joanne Bell; Gene L Bowman; Adam M Brickman; Gaël Chételat; Carrie Ciro; Ann D Cohen; Peggye Dilworth-Anderson; Hiroko H Dodge; Simone Dreux; Steven Edland; Anna Esbensen; Lisbeth Evered; Michael Ewers; Keith N Fargo; Juan Fortea; Hector Gonzalez; Deborah R Gustafson; Elizabeth Head; James A Hendrix; Scott M Hofer; Leigh A Johnson; Roos Jutten; Kerry Kilborn; Krista L Lanctôt; Jennifer J Manly; Ralph N Martins; Michelle M Mielke; Martha Clare Morris; Melissa E Murray; Esther S Oh; Mario A Parra; Robert A Rissman; Catherine M Roe; Octavio A Santos; Nikolaos Scarmeas; Lon S Schneider; Nicole Schupf; Sietske Sikkes; Heather M Snyder; Hamid R Sohrabi; Yaakov Stern; Andre Strydom; Yi Tang; Graciela Muniz Terrera; Charlotte Teunissen; Debora Melo van Lent; Michael Weinborn; Linda Wesselman; Donna M Wilcock; Henrik Zetterberg; Sid E O'Bryant Journal: Alzheimers Dement Date: 2018-12-13 Impact factor: 21.566
Authors: Wayne Silverman; Sharon J Krinsky-McHale; Florence Lai; H Diana Rosas; Christy Hom; Eric Doran; Margaret Pulsifer; Ira Lott; Nicole Schupf Journal: J Appl Res Intellect Disabil Date: 2020-12-13
Authors: James A Hendrix; David C Airey; Angela Britton; Anna D Burke; George T Capone; Ronelyn Chavez; Jacqueline Chen; Brian Chicoine; Alberto C S Costa; Jeffrey L Dage; Eric Doran; Anna Esbensen; Casey L Evans; Kelley M Faber; Tatiana M Foroud; Sarah Hart; Kelsey Haugen; Elizabeth Head; Suzanne Hendrix; Hampus Hillerstrom; Priya S Kishnani; Kavita Krell; Duvia Lara Ledesma; Florence Lai; Ira Lott; Cesar Ochoa-Lubinoff; Jennifer Mason; Jessie Nicodemus-Johnson; Nicholas Kyle Proctor; Margaret B Pulsifer; Carolyn Revta; H Diana Rosas; Tracie C Rosser; Stephanie Santoro; Kim Schafer; Thomas Scheidemantel; Frederick Schmitt; Brian G Skotko; Melissa R Stasko; Amy Talboy; Amy Torres; Kristi Wilmes; Jason Woodward; Jennifer A Zimmer; Howard H Feldman; William Mobley Journal: J Clin Med Date: 2021-04-28 Impact factor: 4.241
Authors: Karly A Cody; Brianna Piro-Gambetti; Matthew D Zammit; Bradley T Christian; Benjamin L Handen; William E Klunk; Shahid Zaman; Sterling C Johnson; David T Plante; Sigan L Hartley Journal: Neurobiol Aging Date: 2020-04-29 Impact factor: 4.673
Authors: James A Hendrix; Angelika Amon; Leonard Abbeduto; Stamatis Agiovlasitis; Tarek Alsaied; Heather A Anderson; Lisa J Bain; Nicole Baumer; Anita Bhattacharyya; Dusan Bogunovic; Kelly N Botteron; George Capone; Priya Chandan; Isabelle Chase; Brian Chicoine; Cécile Cieuta-Walti; Lara R DeRuisseau; Sophie Durand; Anna Esbensen; Juan Fortea; Sandra Giménez; Ann-Charlotte Granholm; Laura J Hahn; Elizabeth Head; Hampus Hillerstrom; Lisa M Jacola; Matthew P Janicki; Joan M Jasien; Angela R Kamer; Raymond D Kent; Bernard Khor; Jeanne B Lawrence; Catherine Lemonnier; Amy Feldman Lewanda; William Mobley; Paul E Moore; Linda Pollak Nelson; Nicolas M Oreskovic; Ricardo S Osorio; David Patterson; Sonja A Rasmussen; Roger H Reeves; Nancy Roizen; Stephanie Santoro; Stephanie L Sherman; Nasreen Talib; Ignacio E Tapia; Kyle M Walsh; Steven F Warren; A Nicole White; Guang William Wong; John S Yi Journal: Transl Sci Rare Dis Date: 2021-04-15
Authors: Sarah E Pape; Tamara Al Janabi; Nicholas J Ashton; Abdul Hye; Rory Sheehan; Paul Gallagher; Bernice Knight; Anne-Marije Prins; Ken Courtenay; Vesna Jordanova; Bini Thomas; Nagarajan Perumal; Craig Forbes; Angela Hassiotis; Andre Strydom Journal: Sci Rep Date: 2021-06-29 Impact factor: 4.379
Authors: Alberto Lleó; Henrik Zetterberg; Jordi Pegueroles; Thomas K Karikari; María Carmona-Iragui; Nicholas J Ashton; Victor Montal; Isabel Barroeta; Juan Lantero-Rodríguez; Laura Videla; Miren Altuna; Bessy Benejam; Susana Fernandez; Silvia Valldeneu; Diana Garzón; Alexandre Bejanin; Maria Florencia Iulita; Valle Camacho; Santiago Medrano-Martorell; Olivia Belbin; Jordi Clarimon; Sylvain Lehmann; Daniel Alcolea; Rafael Blesa; Kaj Blennow; Juan Fortea Journal: Nat Commun Date: 2021-07-14 Impact factor: 14.919