Detection of local tissue alteration during retinal laser photocoagulation of ex vivo porcine eyes using phase-resolved optical coherence tomography.

Retinal laser photocoagulation is used to treat several ophthalmic diseases. However, it is associated with damage to surrounding healthy tissue. Local tissue alteration during coagulation laser illumination was measured using phase-resolved optical coherence tomography (OCT) M-mode scan as a change in the local optical path length (LOPL). A metric that represents global net tissue alteration was defined using the LOPL change. The visibility of a laser lesion was assessed by three-dimensional OCT volume measurement. Multiple logistic regression analysis was performed to investigate the association between the introduced metric and the laser lesion visibility. The metric was found to be a statistically significant predictor of the laser lesion visibility independent to laser condition. The proposed method based on an LOPL change is thus promising for retinal photocoagulation monitoring.