Literature DB >> 28662593

Isolation and structure elucidation of halymeniaol, a new antimalarial sterol derivative from the red alga Halymenia floresii.

Srinu Meesala1, Pratima Gurung1, Krishanpal Karmodiya1, Parameswaran Subrayan2, Milind G Watve1.   

Abstract

A new mono-hydroxy acetylated sterol derivative: 12β-hydroxy-3β, 15α, 16β-triacetoxy-cholest-5-en-7-one (halymeniaol) (1), and cholesterol (2) were isolated from the marine red alga Halymenia floresii. The structure of the compound 1 (halymeniaol) was established from its spectral data, derived from HRMS/MS and 2D NMR. Compound 1 exhibited growth inhibitory activity against chloroquine-resistant Plasmodium falciparum 3D7 strain with an IC50 of 3.0 μM.

Entities:  

Keywords:  Algae; NMR & mass spectrometry; antimalarial activity; natural products; sterols

Mesh：

Substances：

Year:  2017        PMID： 28662593     DOI： 10.1080/10286020.2017.1342636

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  4 in total

Review 1.  Antiplasmodial natural products: an update.

Authors:  Nasir Tajuddeen; Fanie R Van Heerden
Journal:  Malar J       Date:  2019-12-05       Impact factor: 2.979

Review 2.  Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles.

Authors:  Justus Amuche Nweze; Florence N Mbaoji; Yan-Ming Li; Li-Yan Yang; Shu-Shi Huang; Vincent N Chigor; Emmanuel A Eze; Li-Xia Pan; Ting Zhang; Deng-Feng Yang
Journal:  Infect Dis Poverty       Date:  2021-01-22       Impact factor: 4.520

3.  New Halogenated Compounds from Halimeda macroloba Seaweed with Potential Inhibitory Activity against Malaria.

Authors:  Abeer H Elmaidomy; Eman Maher Zahran; Raya Soltane; Ahlam Alasiri; Hani Saber; Che Julius Ngwa; Gabriele Pradel; Faisal Alsenani; Ahmed M Sayed; Usama Ramadan Abdelmohsen
Journal:  Molecules       Date:  2022-08-31       Impact factor: 4.927

Review 4.  Microbial Sterolomics as a Chemical Biology Tool.

Authors:  Brad A Haubrich
Journal:  Molecules       Date:  2018-10-25       Impact factor: 4.411
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.