BACKGROUND/AIMS: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. METHODS: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. RESULTS: EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic β-cells and the size of the islets had increased by β-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZ-induced diabetic rats by reduction of renal fibrosis. CONCLUSION: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabetic rats.
BACKGROUND/AIMS: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabeticrats. METHODS: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. RESULTS:EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic β-cells and the size of the islets had increased by β-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZ-induced diabeticrats by reduction of renal fibrosis. CONCLUSION: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabeticrats.
Authors: Silvano Piovan; Audrei Pavanello; Giuliana Maria Ledesma Peixoto; Camila Cristina Ianoni Matiusso; Ana Maria Praxedes de Moraes; Isabela Peixoto Martins; Ananda Malta; Kesia Palma-Rigo; Claudinéia Conationi da Silva Franco; Paula Gimenez Milani; Antonio Sérgio Dacome; Silvio Claudio da Costa; Paulo Cezar de Freitas Mathias; Cecília Edna Mareze-Costa Journal: Int J Endocrinol Date: 2018-04-29 Impact factor: 3.257
Authors: Paula Gimenez Milani; Silvano Piovan; Yago Carvalho Lima; Maria Rosa Trentin Zorzenon; Carlos Vinicius Dalto da Rosa; Giuliana Maria Ledesma Peixoto; Paulo Cezar de Freitas Mathias; Maria Raquel Marçal Natali; Silvio Claudio da Costa; Cecília Edna Mareze-Costa Journal: J Food Sci Technol Date: 2020-09-25 Impact factor: 2.701
Authors: Veridiana Mota Moreira; Claudinéia Conationi da Silva Franco; Kelly Valério Prates; Rodrigo Mello Gomes; Ana Maria Praxedes de Moraes; Tatiane Aparecida Ribeiro; Isabela Peixoto Martins; Carina Previate; Audrei Pavanello; Camila Cristina Ianoni Matiusso; Douglas Lopes Almeida; Flávio Andrade Francisco; Ananda Malta; Laize Peron Tófolo; Sandra da Silva Silveira; Lucas Paulo Jacinto Saavedra; Katia Machado; Paulo Henrique Olivieri da Silva; Gabriel S Fabrício; Kesia Palma-Rigo; Helenir Medri de Souza; Flaviane de Fátima Silva; Giuliana Regina Biazi; Taís Susane Pereira; Elaine Vieira; Rosiane Aparecida Miranda; Júlio Cezar de Oliveira; Luiz Delmar da Costa Lima; Wilson Rinaldi; Maria Ida Ravanelli; Paulo Cezar de Freitas Mathias Journal: Front Physiol Date: 2018-05-08 Impact factor: 4.566