Literature DB >> 28661856

The use of fibrinogen concentrate for the management of trauma-related bleeding: a systematic review and meta-analysis.

Carlo Mengoli1, Massimo Franchini1,2, Giuseppe Marano1, Simonetta Pupella1, Stefania Vaglio1,3, Marco Marietta4, Giancarlo M Liumbruno1.   

Abstract

Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in this review. A systematic search of the literature identified six retrospective studies and one prospective one, involving 1,650 trauma patients. There were no randomised trials. Meta-analysis showed that fibrinogen concentrate has no effect on overall mortality (risk ratio: 1.07, 95% confidence interval: 0.83-1.38). Although the meta-analytic pooling of the current literature evidence suggests no beneficial effect of fibrinogen concentrate in the setting of severe trauma, the quality of data retrieved was poor and the final results of ongoing randomised trials will help to further elucidate the role of fibrinogen concentrate in traumatic bleeding.

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Year:  2017        PMID： 28661856      PMCID： PMC5490726          DOI： 10.2450/2017.0094-17

Source DB:  PubMed          Journal:  Blood Transfus        ISSN： 1723-2007            Impact factor:   3.443


  43 in total

Review 1.  Coagulopathy and transfusion strategies in trauma. Overwhelmed by literature, supported by weak evidence.

Authors:  Daniele Poole
Journal:  Blood Transfus       Date:  2015-11-20       Impact factor: 3.443

Review 2.  Fibrinogen in traumatic haemorrhage: A narrative review.

Authors:  James Winearls; Don Campbell; Catherine Hurn; Jeremy Furyk; Glenn Ryan; Melita Trout; James Walsham; Anthony Holley; Megan Shuttleworth; Wayne Dyer; Gerben Keijzers; Jeff Presneill; John F Fraser; Martin Wullschleger
Journal:  Injury       Date:  2016-12-26       Impact factor: 2.586

3.  GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

Authors:  Gordon H Guyatt; Andrew D Oxman; Gunn E Vist; Regina Kunz; Yngve Falck-Ytter; Pablo Alonso-Coello; Holger J Schünemann
Journal:  BMJ       Date:  2008-04-26

4.  Fibrinogen concentrate in surgery.

Authors:  Giuseppe Marano; Carlo Mengoli; Massimo Franchini; Stefania Vaglio; Sara Gentili; Simonetta Pupella; Giancarlo M Liumbruno
Journal:  Blood Transfus       Date:  2016-03-09       Impact factor: 3.443

Review 5.  Trauma-induced coagulopathy: from biology to therapy.

Authors:  Pierre Noel; Steven Cashen; Bhavesh Patel
Journal:  Semin Hematol       Date:  2013-07       Impact factor: 3.851

6.  [Coagulation management in trauma-related massive bleeding. - Recommendations of the Task Force for Coagulation (AGPG) of the Austrian Society of Anesthesiology, Resuscitation and Intensive Care Medicine (OGARI)].

Authors:  Dietmar Fries; Petra Innerhofer; Peter Perger; Manfred Gütl; Sabine Heil; Nikolaus Hofmann; Werner Kneifel; Ludwig Neuner; Thomas Pernerstorfer; Georg Pfanner; Herbert Schöchl; Bernhard Ziegler; Camillo Kölblinger; Sibylle Kozek-Langenecker
Journal:  Anasthesiol Intensivmed Notfallmed Schmerzther       Date:  2010-09-13       Impact factor: 0.698

7.  Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate.

Authors:  Herbert Schöchl; Ulrike Nienaber; Georg Hofer; Wolfgang Voelckel; Csilla Jambor; Gisela Scharbert; Sibylle Kozek-Langenecker; Cristina Solomon
Journal:  Crit Care       Date:  2010-04-07       Impact factor: 9.097

8.  The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma.

Authors:  Petra Innerhofer; Isabella Westermann; Helmuth Tauber; Robert Breitkopf; Dietmar Fries; Tobias Kastenberger; Rene El Attal; Alexander Strasak; Markus Mittermayr
Journal:  Injury       Date:  2012-09-20       Impact factor: 2.586

Review 9.  Management of bleeding and coagulopathy following major trauma: an updated European guideline.

Authors:  Donat R Spahn; Bertil Bouillon; Vladimir Cerny; Timothy J Coats; Jacques Duranteau; Enrique Fernández-Mondéjar; Daniela Filipescu; Beverley J Hunt; Radko Komadina; Giuseppe Nardi; Edmund Neugebauer; Yves Ozier; Louis Riddez; Arthur Schultz; Jean-Louis Vincent; Rolf Rossaint
Journal:  Crit Care       Date:  2013-04-19       Impact factor: 9.097

Review 10.  The coagulopathy of trauma: a review of mechanisms.

Authors:  John R Hess; Karim Brohi; Richard P Dutton; Carl J Hauser; John B Holcomb; Yoram Kluger; Kevin Mackway-Jones; Michael J Parr; Sandro B Rizoli; Tetsuo Yukioka; David B Hoyt; Bertil Bouillon
Journal:  J Trauma       Date:  2008-10
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  9 in total

1.  The use of viscoelastic haemostatic assays in non-cardiac surgical settings: a systematic review and meta-analysis.

Authors:  Massimo Franchini; Carlo Mengoli; Mario Cruciani; Marco Marietta; Giuseppe Marano; Stefania Vaglio; Simonetta Pupella; Eva Veropalumbo; Francesca Masiello; Giancarlo M Liumbruno
Journal:  Blood Transfus       Date:  2018-02-26       Impact factor: 3.443

2.  Tranexamic acid to prevent post-partum haemorrhage.

Authors:  Riana Van Der Linde; Emmanuel J Favaloro
Journal:  Blood Transfus       Date:  2018-05-03       Impact factor: 3.443

3.  Dynamic use of fibrinogen under viscoelastic assessment results in reduced need for plasma and diminished overall transfusion requirements in severe trauma.

Authors:  Marta Barquero López; Javier Martínez Cabañero; Alejandro Muñoz Valencia; Clara Sáez Ibarra; Marta De la Rosa Estadella; Andrea Campos Serra; Aurora Gil Velázquez; Gemma Pujol Caballé; Salvador Navarro Soto; Juan Carlos Puyana
Journal:  J Trauma Acute Care Surg       Date:  2022-03-28       Impact factor: 3.697

4.  Fibrinogen inhibits microRNA-19b, a novel mechanism for repair of haemorrhagic shock-induced endothelial cell dysfunction.

Authors:  Amanda M Chipman; Feng Wu; Rosemary A Kozar
Journal:  Blood Transfus       Date:  2021-01-27       Impact factor: 3.443

5.  Pro-coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia.

Authors:  Jez Fabes; Susan J Brunskill; Nicola Curry; Carolyn Doree; Simon J Stanworth
Journal:  Cochrane Database Syst Rev       Date:  2018-12-24

6.  Early Predictive Factors of Hypofibrinogenemia in Acute Trauma Patients.

Authors:  Angeline Neetha Radjou
Journal:  J Emerg Trauma Shock       Date:  2018 Jan-Mar

Review 7.  Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review.

Authors:  Mark Walsh; Ernest E Moore; Hunter B Moore; Scott Thomas; Hau C Kwaan; Jacob Speybroeck; Mathew Marsee; Connor M Bunch; John Stillson; Anthony V Thomas; Annie Grisoli; John Aversa; Daniel Fulkerson; Stefani Vande Lune; Lucas Sjeklocha; Quincy K Tran
Journal:  J Clin Med       Date:  2021-01-17       Impact factor: 4.241

Review 8.  Variations and obstacles in the use of coagulation factor concentrates for major trauma bleeding across Europe: outcomes from a European expert meeting.

Authors:  Vladimir Černý; Marc Maegele; Vanessa Agostini; Dietmar Fries; Santiago R Leal-Noval; Gábor Nardai; Giuseppe Nardi; Anders Östlund; Herbert Schöchl
Journal:  Eur J Trauma Emerg Surg       Date:  2021-01-05       Impact factor: 3.693

9.  Efficacy of prehospital administration of fibrinogen concentrate in trauma patients bleeding or presumed to bleed (FIinTIC): A multicentre, double-blind, placebo-controlled, randomised pilot study.

Authors:  Bernhard Ziegler; Mirjam Bachler; Hubert Haberfellner; Christian Niederwanger; Petra Innerhofer; Tobias Hell; Marc Kaufmann; Marc Maegele; Uriel Martinowitz; Carolin Nebl; Elgar Oswald; Herbert Schöchl; Bettina Schenk; Markus Thaler; Benjamin Treichl; Wolfgang Voelckel; Ivana Zykova; Christine Wimmer; Dietmar Fries
Journal:  Eur J Anaesthesiol       Date:  2021-04-01       Impact factor: 4.183
  9 in total

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