| Literature DB >> 33477257 |
Mark Walsh1,2, Ernest E Moore3,4, Hunter B Moore4, Scott Thomas5, Hau C Kwaan6, Jacob Speybroeck1, Mathew Marsee1, Connor M Bunch1, John Stillson1, Anthony V Thomas1, Annie Grisoli1, John Aversa7, Daniel Fulkerson8, Stefani Vande Lune9, Lucas Sjeklocha10, Quincy K Tran10.
Abstract
This narrative review explores the pathophysiology, geographic variation, and historical developments underlying the selection of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. We also detail a physiologically driven and goal-directed alternative to fixed ratio and whole blood, whereby viscoelastic testing guides the administration of blood components and factor concentrates to the severely bleeding trauma patient. The major studies of each resuscitation method are highlighted, and upcoming comparative trials are detailed.Entities:
Keywords: blood component transfusion; blood transfusion; exsanguination; fibrinogen; hemostatics; thromboelastography
Year: 2021 PMID: 33477257 PMCID: PMC7830337 DOI: 10.3390/jcm10020320
Source DB: PubMed Journal: J Clin Med ISSN: 2077-0383 Impact factor: 4.241