| Literature DB >> 28661155 |
Huawen Huang1, Jinhui Cai1, Hao Xie1, Jing Tan1, Feifei Li1, Guo-Jun Deng1.
Abstract
An NH4I-based reductive system has been explored to promote the oxime N-O bond cleavage and thereby enable a modular synthesis of a broad range of pharmacologically significant fluorinated pyridines. Compared with traditional condensation methods for pyridine assembly, this protocol was found to be highly regio- and chemoselective and presented broad functional group tolerance.Entities:
Year: 2017 PMID： 28661155 DOI： 10.1021/acs.orglett.7b01564
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005