| Literature DB >> 28658408 |
Vanessa van der Linden1,2, Hélio van der Linden3, Mariana de Carvalho Leal4,5, Epitacio Leite Rolim2,4, Ana van der Linden6, Maria de Fátima Viana Vasco Aragão7,8, Alessandra Mertens Brainer-Lima9, Danielle Di Cavalcanti Sousa Cruz6, Liana O Ventura10,11, Telma Lúcia Tabosa Florêncio12, Marli Tenório Cordeiro13, Silvio da Silva Caudas4, Regina Coeli Ramos14.
Abstract
Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.Entities:
Mesh：
Year: 2017 PMID： 28658408 DOI： 10.1590/0004-282X20170066
Source DB: PubMed Journal: Arq Neuropsiquiatr ISSN： 0004-282X Impact factor: 1.420