Literature DB >> 28657073

MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin.

Bo Wu1, Xiao-Qi Li, Tong Huang, Shu-Ting Lu, Bing Wan, Ru-Fang Liao, Yu-Shuang Li, Aju Baidya, Qing-Yun Long, Hai-Bo Xu.   

Abstract

Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd(iii)). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance.

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Year:  2017        PMID： 28657073     DOI： 10.1039/c7bm00431a

Source DB:  PubMed          Journal:  Biomater Sci        ISSN： 2047-4830            Impact factor:   6.843


  8 in total

1.  Porphyrin-Based Tumor-Targeting Theranostic Agent: Gd-TDAP.

Authors:  Soyeon Kim; Ji-Ung Yang; Jae Hun Ahn; In Ok Ko; Jung Young Kim; Yong Jin Lee; Ji-Ae Park
Journal:  ACS Med Chem Lett       Date:  2021-08-13       Impact factor: 4.632

2.  Hyaluronic Acid Grafted Nanoparticles of a Platinum(II)-Silicon(IV) Phthalocyanine Conjugate for Tumor and Mitochondria-Targeted Photodynamic Therapy in Red Light.

Authors:  Koushambi Mitra; Montserrat Samso; Charles E Lyons; Matthew C T Hartman
Journal:  J Mater Chem B       Date:  2018-10-24       Impact factor: 6.331

Review 3.  Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer.

Authors:  Yanan Li; Jingqi Xin; Yongbing Sun; Tao Han; Hui Zhang; Feifei An
Journal:  Cancer Biol Med       Date:  2020-05-15       Impact factor: 4.248

4.  Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment.

Authors:  Dan Xu; Shu-Ting Lu; Yu-Shuang Li; Aju Baidya; Hao Mei; Yong He; Bo Wu
Journal:  Drug Des Devel Ther       Date:  2018-10-05       Impact factor: 4.162

5.  Aggregation-Induced Emission (AIE) Polymeric Micelles for Imaging-Guided Photodynamic Cancer Therapy.

Authors:  Yang Zhang; Cai-Xia Wang; Shi-Wen Huang
Journal:  Nanomaterials (Basel)       Date:  2018-11-07       Impact factor: 5.076

6.  Gd(iii)-Pt(iv) theranostic contrast agents for tandem MR imaging and chemotherapy.

Authors:  Casey J Adams; Thomas J Meade
Journal:  Chem Sci       Date:  2020-01-28       Impact factor: 9.825

Review 7.  Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer.

Authors:  Paromita Sarbadhikary; Blassan P George; Heidi Abrahamse
Journal:  Theranostics       Date:  2021-08-26       Impact factor: 11.556

8.  Towards Imaging Pt Chemoresistance Using Gd(III)-Pt(II) Theranostic MR Contrast Agents.

Authors:  Casey J Adams; Thomas J Meade
Journal:  ChemMedChem       Date:  2021-08-06       Impact factor: 3.466
  8 in total

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