| Literature DB >> 28654869 |
Patricia I Mathias1, Thomas H Connor2, Clayton B'Hymer2.
Abstract
This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research. Published by Elsevier B.V.Entities:
Keywords: Anticancer drugs; Antineoplastic drug; Liquid chromatography mass spectrometry; Occupational biomonitoring; Urinary biomarker
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Year: 2017 PMID: 28654869 PMCID: PMC5585056 DOI: 10.1016/j.jchromb.2017.06.028
Source DB: PubMed Journal: J Chromatogr B Analyt Technol Biomed Life Sci ISSN: 1570-0232 Impact factor: 3.205