| Literature DB >> 28651492 |
Long Huang1,2,3, Yun Zhou1,2,4, Xin-Ping Cao2,4,5, Jia-Xin Lin6, Lan Zhang1,2,4, Shu-Ting Huang1,2,4, Min Zheng1,2,4.
Abstract
This study aimed to determine whether serum karyopherin alpha 2 levels can be used as a diagnostic biomarker for epithelial ovarian carcinoma. Karyopherin alpha 2 protein was detected by enzyme-linked immunosorbent assay in serum samples from 162 epithelial ovarian carcinoma patients and 48 healthy controls. Serum karyopherin alpha 2 levels in epithelial ovarian carcinoma patients were significantly higher than in healthy controls ( p < 0.001). When a karyopherin alpha 2 serum level of 2.52 µg/mL was used as a cut-off, the sensitivity and specificity of the assay for diagnosing epithelial ovarian carcinoma were 71.4% and 81.2%, respectively. High serum karyopherin alpha 2 levels (>485 µg/mL) correlated with International Federation of Gynecology and Obstetrics stage ( p < 0.0001), lymphatic metastasis ( p = 0.045), overall survival ( p = 0.001), and disease-free progression ( p = 0.006). Serum karyopherin alpha 2 represents a potential diagnostic biomarker for epithelial ovarian carcinoma.Entities:
Keywords: Karyopherin alpha 2; biomarker; epithelial ovarian carcinoma; serum
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Year: 2017 PMID： 28651492 DOI： 10.1177/1010428317706289
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283