Literature DB >> 28651237

The many postures of noncanonical Wnt signaling in development and diseases.

Qian Xiao1, Zhengxi Chen2, Xiaozhuang Jin3, Runyi Mao4, Zhenqi Chen5.   

Abstract

Wnt signaling regulates many aspects of vertebrate development. Its dysregulation causes developmental defects and diseases including cancer. The signaling can be categorized in two pathways: canonical and noncanonical. Canonical pathway plays a key role in regulating proliferation and differentiation of cells whilst noncanonical Wnt signaling mainly controls cellular polarity and motility. During development, noncanonical Wnt signaling is required for tissue formation. Recent studies have shown that noncanonical Wnt signaling is involved in adult tissue development and cancer progression. In this review, we try to describe and discuss the mechanisms behind the biological effects of noncanonical Wnt signaling, diseases caused by its dysregulation, and implications in adult tissue development biology.
Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Development; Disease; Noncanonical wnt signaling; Review

Mesh：

Substances：

Year:  2017        PMID： 28651237     DOI： 10.1016/j.biopha.2017.06.061

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  13 in total

Review 1.  Two Sides of the Same Coin: The Role of Developmental pathways and pluripotency factors in normal mammary stem cells and breast cancer metastasis.

Authors:  M U J Oliphant; Deguang Kong; Hengbo Zhou; M T Lewis; H L Ford
Journal:  J Mammary Gland Biol Neoplasia       Date:  2020-04-22       Impact factor: 2.673

Review 2.  The role of Wnt/mTOR signaling in spinal cord injury.

Authors:  Peng Cheng; Hai-Yang Liao; Hai-Hong Zhang
Journal:  J Clin Orthop Trauma       Date:  2022-01-04

3.  Canonical and non-canonical Wnt signal pathway in classic Hodgkin lymphoma and the prognostic significance of LEF1, β-catenin, FZD6 and Wnt5a/b.

Authors:  Linlin Gao; Wei Cui; Sarah Kelting; Janet Woodroof; Hua Li; Linheng Li; Da Zhang
Journal:  Am J Blood Res       Date:  2022-08-15

4.  Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage.

Authors:  Keane K Y Lai; Cu Nguyen; Kyung-Soon Lee; Albert Lee; David P Lin; Jia-Ling Teo; Michael Kahn
Journal:  Curr Mol Pharmacol       Date:  2019       Impact factor: 3.339

Review 5.  Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities.

Authors:  Xiufang Xu; Miaofeng Zhang; Faying Xu; Shaojie Jiang
Journal:  Mol Cancer       Date:  2020-11-24       Impact factor: 27.401

6.  DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.

Authors:  Jiajia Hu; Zhengting Wang; Zhengxi Chen; Ao Li; Jing Sun; Minhua Zheng; Jibo Wu; Tianli Shen; Ju Qiao; Lin Li; Biao Li; Dianqing Wu; Qian Xiao
Journal:  Biomed Pharmacother       Date:  2020-05-20       Impact factor: 6.529

7.  Functional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancer.

Authors:  Miriam Nuncia-Cantarero; Sandra Martinez-Canales; Fernando Andrés-Pretel; Gabriel Santpere; Alberto Ocaña; Eva Maria Galan-Moya
Journal:  Breast Cancer Res Treat       Date:  2018-01-12       Impact factor: 4.872

8.  Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth.

Authors:  Cecilia Dyberg; Teodora Andonova; Thale Kristin Olsen; Bertha Brodin; Marcel Kool; Per Kogner; John Inge Johnsen; Malin Wickström
Journal:  Cancers (Basel)       Date:  2019-12-26       Impact factor: 6.639

Review 9.  Noncanonical Wnt planar cell polarity signaling in lung development and disease.

Authors:  Eszter K Vladar; Melanie Königshoff
Journal:  Biochem Soc Trans       Date:  2020-02-28       Impact factor: 5.407

10.  The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation.

Authors:  Nicholas W Chavkin; Soichi Sano; Ying Wang; Kosei Oshima; Hayato Ogawa; Keita Horitani; Miho Sano; Susan MacLauchlan; Anders Nelson; Karishma Setia; Tanvi Vippa; Yosuke Watanabe; Jeffrey J Saucerman; Karen K Hirschi; Noyan Gokce; Kenneth Walsh
Journal:  J Am Heart Assoc       Date:  2021-06-22       Impact factor: 5.501
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.