Literature DB >> 2864922

A study on the mechanism of the epimerization at C-3 of chenodeoxycholic acid by Clostridium perfringens.

F Aragozzini, E Canzi, A Ferrari, E Maconi, A Sidjimov.   

Abstract

The mechanism of 3-hydroxy epimerization of chenodeoxycholic acid by Clostridium perfringens was investigated in 3 alpha, 7 alpha-dihydroxy-[2,2,4,4-2H4]-, 3 alpha, 7 alpha-dihydroxy-[3 beta-2H]- and 3 beta, 7 alpha-dihydroxy-[3 alpha-2H]-5 beta-cholanoic acid transformations. Our findings rule out a dehydration-rehydration pathway and agree with a redox mechanism involving 3-oxochenodeoxycholic acid as intermediate.

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Year:  1985        PMID： 2864922      PMCID： PMC1152636          DOI： 10.1042/bj2300451

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  Reversible enzymatic oxidation of bile acids.

Authors:  O HAYAISHI; Y SATO; W B JAKOBY; E F STOHLMAN
Journal:  Arch Biochem Biophys       Date:  1955-06       Impact factor: 4.013

2.  Ursodeoxycholic acid versus chenodeoxycholic acid. Comparison of their effects on bile acid and bile lipid composition in patients with cholesterol gallstones.

Authors:  A Stiehl; P Czygan; B Kommerell; H J Weis; K H Holtermüller
Journal:  Gastroenterology       Date:  1978-12       Impact factor: 22.682

3.  Chenodeoxycholic acid treatment of gallstones. A follow-up report and analysis of factors influencing response to therapy.

Authors:  J H Iser; H Dowling; H Y Mok; G D Bell
Journal:  N Engl J Med       Date:  1975-08-21       Impact factor: 91.245

4.  Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.

Authors:  G Salen; G S Tint; B Eliav; N Deering; E H Mosbach
Journal:  J Clin Invest       Date:  1974-02       Impact factor: 14.808

5.  Transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal bacteria.

Authors:  T Fedorowski; G Salen; G S Tint; E Mosbach
Journal:  Gastroenterology       Date:  1979-11       Impact factor: 22.682

6.  Transformation of bile acids by Clostridium perfringens.

Authors:  S Hirano; N Masuda; H Oda; H Mukai
Journal:  Appl Environ Microbiol       Date:  1981-09       Impact factor: 4.792

7.  Transformation of bile acids by Eubacterium lentum.

Authors:  S Hirano; N Masuda
Journal:  Appl Environ Microbiol       Date:  1981-11       Impact factor: 4.792

8.  Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum.

Authors:  I A MacDonald; P D Roach
Journal:  Biochim Biophys Acta       Date:  1981-08-24

9.  Formation of urso- and ursodeoxy-cholic acids from primary bile acids by Clostridium absonum.

Authors:  I A Macdonald; D M Hutchison; T P Forrest
Journal:  J Lipid Res       Date:  1981-03       Impact factor: 5.922

10.  Ursodeoxycholic acid treatment of gallstones. Dose-response study and possible mechanism of action.

Authors:  P N Maton; G M Murphy; R H Dowling
Journal:  Lancet       Date:  1977 Dec 24-31       Impact factor: 79.321
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  1 in total

1.  Partial purification and characterization of an NAD-dependent 3 beta-hydroxysteroid dehydrogenase from Clostridium innocuum.

Authors:  R Edenharder; M Pfützner
Journal:  Appl Environ Microbiol       Date:  1989-06       Impact factor: 4.792
  1 in total

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