| Literature DB >> 28648185 |
R Steven Conlan1, Simone Pisano2, Marta I Oliveira3, Mauro Ferrari4, Inês Mendes Pinto5.
Abstract
Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or 'exosomes'. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28648185 PMCID： PMC5657340 DOI： 10.1016/j.molmed.2017.05.003
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 15.272