Talissa A Altes1, Craig H Meyer2, Jaime F Mata3, Deborah K Froh4, Alix Paget-Brown4, W Gerald Teague4, Sean B Fain5, Eduard E de Lange3, Kai Ruppert6, Martyn C Botfield7, Mac A Johnson7, John P Mugler2. 1. Department of Radiology, University of Missouri, Columbia, MO, United States; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States. Electronic address: altest@health.missouri.edu. 2. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States. 3. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States. 4. Department of Pediatrics, University of Virginia, Charlottesville, VA, United States. 5. Department of Medical Physics and Radiology, University of Wisconsin, Madison, WI, United States. 6. Department of Radiology University of Pennsylvania, Philadelphia, PA, United States. 7. Vertex Pharmaceuticals Incorporated, Boston, MA, United States.
Abstract
PURPOSE: To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. MATERIALS AND METHODS: HHe ventilation MRI was performed on seven children ≤4years old. Contiguous 2D-spiral helium-3 images were acquired sequentially with a scan time of ≤0.2s/slice. RESULTS: Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. CONCLUSION: HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age.
PURPOSE: To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. MATERIALS AND METHODS: HHe ventilation MRI was performed on seven children ≤4years old. Contiguous 2D-spiral helium-3 images were acquired sequentially with a scan time of ≤0.2s/slice. RESULTS: Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. CONCLUSION: HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age.
Authors: Nanae Tsuchiya; Mark L Schiebler; Michael D Evans; Robert V Cadman; Ronald L Sorkness; Robert F Lemanske; Daniel J Jackson; Nizar N Jarjour; Loren C Denlinger; Sean B Fain Journal: Pediatr Radiol Date: 2020-01-24
Authors: Luis Torres; Jeff Kammerman; Andrew D Hahn; Wei Zha; Scott K Nagle; Kevin Johnson; Nathan Sandbo; Keith Meyer; Mark Schiebler; Sean B Fain Journal: Acad Radiol Date: 2019-01-16 Impact factor: 3.173
Authors: Nara S Higano; Robert P Thomen; James D Quirk; Heidie L Huyck; Andrew D Hahn; Sean B Fain; Gloria S Pryhuber; Jason C Woods Journal: Neonatology Date: 2020-11-11 Impact factor: 4.035
Authors: Jason C Woods; Jim M Wild; Mark O Wielpütz; John P Clancy; Hiroto Hatabu; Hans-Ulrich Kauczor; Edwin J R van Beek; Talissa A Altes Journal: J Magn Reson Imaging Date: 2019-12-17 Impact factor: 4.813
Authors: Paul J C Hughes; Laurie Smith; Ho-Fung Chan; Bilal A Tahir; Graham Norquay; Guilhem J Collier; Alberto Biancardi; Helen Marshall; Jim M Wild Journal: J Appl Physiol (1985) Date: 2018-11-09
Authors: Nara S Higano; David R Spielberg; Robert J Fleck; Andrew H Schapiro; Laura L Walkup; Andrew D Hahn; Jean A Tkach; Paul S Kingma; Stephanie L Merhar; Sean B Fain; Jason C Woods Journal: Am J Respir Crit Care Med Date: 2018-11-15 Impact factor: 30.528
Authors: Nara S Higano; Alister J Bates; Chamindu C Gunatilaka; Erik B Hysinger; Paul J Critser; Russel Hirsch; Jason C Woods; Robert J Fleck Journal: Pediatr Radiol Date: 2022-02-05